Sugi Predict

Sugi Predict / Compounds / SCHEMBL500460

SCHEMBL500460

SCHEMBL500460

COC(=O)[C@@H](N)C(C)(C)C

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ DPP4 P27487 6/20 0.41
▸ ALDH1A1 P00352 2/20 0.37
▸ MAPT P10636 1/20 0.37
▸ PTGS1 P23219 1/20 0.37
▸ CA14 Q9ULX7 3/20 0.37
▸ CA12 O43570 2/20 0.37
▸ DGAT1 O75907 1/20 0.36
▸ CA1 P00915 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ KMT2A Q03164 1/20 0.32
▸ SLC1A3 P43003 1/20 0.31
▸ SLC1A2 P43004 1/20 0.31
▸ SLC1A1 P43005 1/20 0.31
▸ FAP Q12884 1/20 0.31
▸ DPP8 Q6V1X1 1/20 0.31
▸ DPP9 Q86TI2 1/20 0.31
▸ DPP7 Q9UHL4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL500459 1.00 SMN1; SMN2 (0.42) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
SCHEMBL20879474 1.00 SMN1; SMN2 (0.42) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
Hydrochloric Acid SCHEMBL29398329 0.97 SMN1; SMN2 (0.41) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
Hydrochloric Acid SCHEMBL1705950 0.97 SMN1; SMN2 (0.41) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
Hydrochloric Acid SCHEMBL737492 0.97 SMN1; SMN2 (0.41) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
SCHEMBL3015800 0.82 SMN1; SMN2 (0.39) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
SCHEMBL16147546 0.82 SMN1; SMN2 (0.39) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
SCHEMBL255215 0.82 SMN1; SMN2 (0.39) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
SCHEMBL16821022 0.82 SMN1; SMN2 (0.39) SMN1; SMN2DPP4ALDH1A1MAPTPTGS1
SCHEMBL7540176 0.81 ALDH1A1 (0.39) DPP4ALDH1A1MAPTPTGS1FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 309 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122010765-A Asymmetric alpha-amino acid or polypeptide derivative and preparation method and application thereof 中国科学技术大学 2026-05-12 — — CN claimed
CN-119661396-A Preparation method of gamma-amino acid derivative or dipeptide 中国科学院大连化学物理研究所 2025-03-21 — — CN claimed
CN-115850146-A Synthetic cannabinoid hapten compound and preparation method and application thereof 上海市禁毒委员会办公室 2023-03-28 — — CN claimed
CN-115304516-A Compounds with unconventional chromophores, their preparation and use 四川大学 2022-11-08 — — CN claimed
EP-2398774-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS Incyte Corporation (US) 2011-12-28 — — EP claimed
EP-2215076-A2 COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION Virobay, Inc. (US) 2010-08-11 — — EP claimed
WO-2010083283-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2010-07-22 — — WO claimed
US-20090270415-A1 COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION VIROBAY, INC. (US) 2009-10-29 — — US claimed
WO-2009055467-A2 COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION VIROBAY, INC. (US) 2009-04-30 — — WO claimed
US-12630498-B2 Arylamides and methods of use thereof GENZYME CORPORATION (US) 2026-05-19 — — US disclosed
US-12630521-B2 Arylamides and methods of use thereof GENZYME CORPORATION (US) 2026-05-19 — — US disclosed
WO-2026102082-A1 ALKYLPHENYL SUBSTITUTED COMPOUNDS, COMPOSITIONS AND METHODS OF USE DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-15 — — WO disclosed
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-14 — — US disclosed
CN-122010765-A Asymmetric alpha-amino acid or polypeptide derivative and preparation method and application thereof 中国科学技术大学 2026-05-12 — — CN disclosed
EP-1008592-A2 Cyclic amide derivatives which inhibit cathepsin K Fujirebio Kabushiki Kaisha (JP) 2000-06-14 — — EP disclosed
EP-0712390-B1 SUCCINAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS GELATINASE AND COLLAGENASE INHIBITORS CELLTECH THERAPEUTICS LTD (GB) 1998-12-09 — — EP disclosed
US-5827890-A ANGIOGENESIS INHIBITORS CELLTECH THERAPEUTICS LTD. (GB) 1998-10-27 — — US disclosed
EP-0443983-B1 Acyl compounds CIBA GEIGY AG (CH) 1996-02-28 — — EP disclosed
WO-1995004033-A1 SUCCINAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS GELATINASE AND COLLAGENASE INHIBITORS CELLTECH LIMITED (GB) 1995-02-09 — — WO disclosed
EP-0443983-A1 Acyl compounds CIBA-GEIGY AG (CH) 1991-08-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090270415-A1 COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION CTSS, CTSV, CTSE SMN1; SMN2 3554/4885DPP4 120/4885ALDH1A1 3330/4885
US-12630521-B2 Arylamides and methods of use thereof CFTR, CLIC1, CLCN2 SMN1; SMN2 2502/4885DPP4 2709/4885ALDH1A1 905/4885
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use GIPR, MC2R, GRPR SMN1; SMN2 881/4885DPP4 267/4885ALDH1A1 3360/4885
US-12630498-B2 Arylamides and methods of use thereof CFTR, CLIC1, CLCN2 SMN1; SMN2 2901/4885DPP4 2412/4885ALDH1A1 775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.