Sugi Predict

Sugi Predict / Compounds / SCHEMBL5010340

SCHEMBL5010340

SCHEMBL5010340

O=C(Cl)NN1CCC(N2CCCCC2)CC1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL3 Q96JM7 10/20 0.45
▸ L3MBTL1 Q9Y468 9/20 0.45
▸ MBTD1 Q05BQ5 5/20 0.45
▸ TP53BP1 Q12888 2/20 0.42
▸ L3MBTL4 Q8NA19 1/20 0.42
▸ CYP3A4 P08684 1/20 0.40
▸ CYP2D6 P10635 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ ALDH1A1 P00352 2/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ SIGMAR1 Q99720 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6202425 0.98 L3MBTL3 (0.44) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4
SCHEMBL10402992 0.83 L3MBTL3 (0.46) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4
SCHEMBL3268930 0.83 L3MBTL3 (0.46) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4
SCHEMBL2891503 0.80 HTT (0.45) L3MBTL1CYP3A4ALDH1A1KDM4E
SCHEMBL7430647 0.80 HTT (0.45) L3MBTL1CYP3A4ALDH1A1KDM4E
SCHEMBL364908 0.77 — —
SCHEMBL1401624 0.75 L3MBTL3 (0.58) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4
SCHEMBL9714622 0.74 L3MBTL3 (0.38) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4
SCHEMBL7034365 0.74 L3MBTL3 (0.39) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4
Hydrochloric Acid SCHEMBL457517 0.73 L3MBTL3 (0.56) L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208050-A1 PROCESS FOR PREPARING IRINOTECAN DR. REDDY'S LABORATORIES LIMITED (IN) 2007-09-06 — — US claimed
EP-1796670-A1 PROCESS TO PREPARE CAMPTOTHECIN DERIVATIVES AND NOVEL INTERMEDIATE AND COMPOUNDS THEREOF Chatham Biotec Ltd. (CA) 2007-06-20 — — EP claimed
WO-2005117881-A1 PROCESS TO PREPARE CAMPTOTHECIN DERIVATIVES AND NOVEL INTERMEDIATE AND COMPOUNDS THEREOF CHATHAM BIOTEC LTD. (CA) 2005-12-15 — — WO claimed
US-20050272757-A1 Process to prepare camptothecin derivatives and novel intermediate and compounds thereof PHYTOGEN LIFE SCIENCES INC. (CA) 2005-12-08 — — US claimed
EP-1501799-A1 COMPOUNDS USEFUL IN PREPARING CAMPTOTHECIN DERIVATIVES Pharmacia Corporation (US) 2005-02-02 — — EP claimed
US-6723729-B2 CHEMICAL INTERMEDIATES FOR ANTICARCINOGENIC AGENT IRINOTECAN PHARMACIA AND UPJOHN COMPANY 2004-04-20 — — US claimed
US-20040048832-A1 Compounds useful in preparing camptothecin derivatives PHARMACIA CORPORATION 2004-03-11 — — US claimed
WO-2003089413-A1 PHARMACIA CORPORATION PHARMACIA CORPORATION (US) 2003-10-30 — — WO claimed
CN-112759603-B Podophyllotoxin derivative and application thereof 加州太平洋医疗中心 2022-09-09 — — CN disclosed
US-11186594-B2 Podophyllotoxin derivatives and their use CALIFORNIA PACIFIC MEDICAL CENTER (US) 2021-11-30 — — US disclosed
CN-112759603-A Podophyllotoxin derivative and application thereof 加州太平洋医疗中心 2021-05-07 — — CN disclosed
CN-106937529-B Podophyllotoxin derivative and application thereof 加州太平洋医疗中心 2021-02-05 — — CN disclosed
US-20200277310-A1 PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE CALIFORNIA PACIFIC MEDICAL CENTER (US) 2020-09-03 — — US disclosed
EP-3371192-B1 PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE CALIFORNIA PACIFIC MEDICAL CENTER (US) 2020-06-03 — — EP disclosed
EP-1140745-A1 COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS Angiogene Pharmaceuticals Ltd (GB) 2001-10-10 — — EP disclosed
US-6235907-B1 Intermediates useful in making mappicine and related compounds PHARMACIA & UPJOHN COMPANY 2001-05-22 — — US disclosed
US-6121451-A Intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds PHARMACIA & UPJOHN COMPANY (US) 2000-09-19 — — US disclosed
WO-2000040529-A1 COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS ANGIOGENE PHARMACEUTICALS LTD. (GB) 2000-07-13 — — WO disclosed
EP-0835257-A1 NOVEL INTERMEDIATES AND PROCESS FOR THE MANUFACTURE OF CAMPTOTHECIN DERIVATIVES (CPT-11) AND RELATED COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1998-04-15 — — EP disclosed
WO-1996031513-A1 NOVEL INTERMEDIATES AND PROCESS FOR THE MANUFACTURE OF CAMPTOTHECIN DERIVATIVES (CPT-11) AND RELATED COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1996-10-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200277310-A1 PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE CASP7, CASP3, PTMA L3MBTL3 1313/4885L3MBTL1 1542/4885MBTD1 2447/4885
US-20040048832-A1 Compounds useful in preparing camptothecin derivatives TOP2A, TOP2B, TOP1 L3MBTL3 1903/4885L3MBTL1 2618/4885MBTD1 3768/4885
US-20050272757-A1 Process to prepare camptothecin derivatives and novel intermediate and compounds thereof TOP2A, TOP2B, TOP1 L3MBTL3 4677/4885L3MBTL1 4652/4885MBTD1 3804/4885
US-11186594-B2 Podophyllotoxin derivatives and their use CASP7, CASP3, PTMA L3MBTL3 1313/4885L3MBTL1 1542/4885MBTD1 2447/4885
US-20070208050-A1 PROCESS FOR PREPARING IRINOTECAN SI, TYMP, TOP1 L3MBTL3 4774/4885L3MBTL1 4799/4885MBTD1 3796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.