Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.38 |
| ▸ | TUBB | P07437 | 2/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790835 | 0.72 | CYP2C9 (0.47) | ALDH1A1LMNAMAPTTSHRCYP1A2 | |
| SCHEMBL2535686 | 0.70 | TSHR (0.42) | ALDH1A1LMNAMAPTMAPK1PKM | |
| SCHEMBL7480109 | 0.69 | MAPT (0.45) | KDM4EALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL95841 | 0.68 | ALDH1A1 (0.39) | KDM4EALDH1A1MAPTTDP1SMN1; SMN2 | |
| SCHEMBL16294301 | 0.68 | RAB9A (0.36) | KDM4E | |
| SCHEMBL21305541 | 0.68 | MEN1 (0.43) | KDM4EALDH1A1TSHRL3MBTL1 | |
| SCHEMBL1416233 | 0.67 | ALOX5 (0.34) | ALDH1A1MAPTTDP1SMN1; SMN2TSHR | |
| SCHEMBL482524 | 0.64 | KMT2A (0.45) | KDM4EALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL27995633 | 0.64 | KDM4E (0.45) | KDM4EALDH1A1MAPTMAPK1TUBB1 | |
| SCHEMBL1416613 | 0.64 | ROCK2 (0.35) | ALDH1A1LMNAPKMSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1138673-B1 | Novel carbamates and ureas as modifiers of multi-drug resistance | VERTEX PHARMA (US) | 2008-08-06 | — | — | EP | claimed |