Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP4 | P49662 | 1/20 | 0.38 |
| ▸ | CASP5 | P51878 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090128 | 0.85 | MGLL (0.37) | KDM4EALDH1A1GAAHTR1ALMNA | |
| SCHEMBL2092360 | 0.80 | SCN9A (0.37) | HTR1AMEN1KMT2A | |
| SCHEMBL5015079 | 0.77 | DRD2 (0.41) | DRD2DRD4DRD3HTR1AMEN1 | |
| SCHEMBL5540624 | 0.75 | DRD4 (0.52) | DRD2DRD4DRD3KDM4EALDH1A1 | |
| SCHEMBL5011767 | 0.75 | HRH3 (0.45) | DRD2HTR1A | |
| SCHEMBL5015107 | 0.75 | GNRHR (0.44) | DRD2DRD4DRD3KDM4EALDH1A1 | |
| SCHEMBL5013346 | 0.74 | KDM4E (0.45) | DRD2DRD4DRD3KDM4EALDH1A1 | |
| SCHEMBL5016310 | 0.74 | HRH3 (0.48) | DRD2HTR1A | |
| SCHEMBL5012719 | 0.73 | HRH1 (0.49) | DRD2HTR1A | |
| SCHEMBL5016131 | 0.72 | ALDH1A1 (0.51) | DRD4DRD3KDM4EALDH1A1GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |