SCHEMBL501733

SCHEMBL501733

Cc1ccc(C)c(C([O])=O)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55
TSHR P16473 1/20 0.51
CSNK2A1 P68400 1/20 0.48
SMN1; SMN2 Q16637 3/20 0.45
GAA P10253 1/20 0.44
HSD17B10 Q99714 1/20 0.42
ALDH1A1 P00352 3/20 0.42
MAPT P10636 3/20 0.42
LMNA P02545 2/20 0.42
RAB9A P51151 2/20 0.42
MITF O75030 1/20 0.42
S1PR4 O95977 1/20 0.42
S1PR1 P21453 1/20 0.42
HTT P42858 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
NPC1 O15118 2/20 0.41
HPGD P15428 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9862051 0.83 MEN1 (0.57) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
SCHEMBL9420245 0.83 MEN1 (0.57) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
SCHEMBL501730 0.81 NFE2L2 (0.49) MEN1KMT2ACSNK2A1SMN1; SMN2ALDH1A1
SCHEMBL697905 0.81 KMT2A (0.55) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
SCHEMBL223101 0.81 CSNK2A1 (0.65) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
SCHEMBL29636568 0.81 KMT2A (0.55) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
Iodide SCHEMBL6113218 0.79 CSNK2A1 (0.63) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
Bromide SCHEMBL6112907 0.79 CSNK2A1 (0.63) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
SCHEMBL20853603 0.79 CSNK2A1 (0.69) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2
SCHEMBL6916095 0.79 CSNK2A1 (0.63) MEN1KMT2ATSHRCSNK2A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906279-B2 Manufacturing method of polarizing plate protective film, polarizing plate protective film, polarizing plate, and liquid crystal display device KONICA MINOLTA OPTO, INC. (JP) 2014-12-09 US disclosed
US-8569405-B2 Additive mixtures for styrenic polymers BASF SE (DE) 2013-10-29 US disclosed
US-8518302-B2 Stabilization of organic materials BASF SE (DE) 2013-08-27 US disclosed
US-8252862-B2 Silane coupling agents for filled rubbers BASF SE (DE) 2012-08-28 US disclosed
US-20120142988-A1 METHOD OF PRODUCING 1-HEXENE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-07 US disclosed
US-20120088869-A1 STABILIZATION OF ORGANIC MATERIALS GERSTER MICHELE (CH) 2012-04-12 US disclosed
US-8119710-B2 Filled rubber compounds with improved processability BASF SE (DE) 2012-02-21 US disclosed
US-8105504-B2 Stabilization of organic materials BASF SE (DE) 2012-01-31 US disclosed
EP-2190912-B1 SILANE COUPLING AGENTS FOR FILLED RUBBERS BASF SE (DE) 2011-11-23 EP disclosed
EP-2238199-B1 ADDITIVE MIXTURES FOR STYRENIC POLYMERS BASF SE (DE) 2011-08-31 EP disclosed
US-5428177-A For protecting organic materials against thermal, oxidative or light-induced degradation CIBA-GEIGY CORPORATION (US) 1995-06-27 US disclosed
US-5428162-A For protecting organic materials against thermal, oxidative or light-induced degradation CIBA-GEIGY CORPORATION (US) 1995-06-27 US disclosed
EP-0648765-A1 Process for the production of 3-arylbenzofuranones CIBA-GEIGY AG (CH) 1995-04-19 EP disclosed
EP-0644190-A1 Benzofuran-2-ones as stabilizers CIBA-GEIGY AG (CH) 1995-03-22 EP disclosed
US-5369159-A Heat, oxidation and radiation resistance for polymers CIBA-GEIGY CORPORATION (US) 1994-11-29 US disclosed
US-5367008-A 3-(alkoxyphenyl)benzofuran-2-ones as stabilisers CIBA-GEIGY CORPORATION (US) 1994-11-22 US disclosed
US-5356966-A Stabilizing organic material against oxidative, thermal or light iinduced degradation CIBA-GEIGY CORPORATION (US) 1994-10-18 US disclosed
EP-0608198-A1 Cyclic diphenylacetonenitriles as stabilisers CIBA-GEIGY AG (CH) 1994-07-27 EP disclosed
EP-0591102-A1 3-(2-Acyloxyethoxyphenyl)benzofuran-2-ones as stabilizers CIBA-GEIGY AG (CH) 1994-04-06 EP disclosed
EP-0589839-A1 3-(Dihydrobenzofuran-5-yl)benzofuran-2-ones as stabilizers CIBA-GEIGY AG (CH) 1994-03-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142988-A1 METHOD OF PRODUCING 1-HEXENE HRH1, HK1, HMOX1 MEN1 250/4885KMT2A 2250/4885TSHR 3345/4885
US-20120088869-A1 STABILIZATION OF ORGANIC MATERIALS LPO, AOX1, SOD1 MEN1 2360/4885KMT2A 2949/4885TSHR 4649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.