Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201108 | 0.88 | LMNA (0.38) | MEN1LMNAL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL5023358 | 0.81 | NAMPT (0.37) | MEN1SMN1; SMN2TSHRKMT2AALDH1A1 | |
| SCHEMBL5016836 | 0.76 | L3MBTL1 (0.36) | MEN1LMNAL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL13523826 | 0.74 | RBP4 (0.41) | — | |
| SCHEMBL3047511 | 0.74 | RBP4 (0.41) | — | |
| SCHEMBL13201225 | 0.68 | FPR3 (0.42) | MEN1LMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL3047512 | 0.67 | RBP4 (0.41) | — | |
| SCHEMBL5458110 | 0.66 | RBP4 (0.41) | — | |
| SCHEMBL5023849 | 0.66 | LMNA (0.40) | MEN1LMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL2959095 | 0.66 | RBP4 (0.48) | LMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | claimed |