Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | CTSG | P08311 | 2/20 | 0.33 |
| ▸ | KLK7 | P49862 | 2/20 | 0.33 |
| ▸ | KLK14 | Q9P0G3 | 2/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030908 | 0.74 | HSD11B1 (0.40) | BAZ2BBAZ2ARAB9AALDH1A1KDM4E | |
| SCHEMBL5536155 | 0.69 | CYP2A6 (0.40) | RAB9AALDH1A1KDM4EKMT2AHSD11B1 | |
| SCHEMBL5376166 | 0.69 | ALDH1A1 (0.40) | RAB9AALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL1970261 | 0.67 | HSD11B1 (0.40) | BAZ2BBAZ2ARAB9AALDH1A1KDM4E | |
| SCHEMBL937206 | 0.66 | PTGS2 (0.61) | RAB9AALDH1A1KDM4EKMT2AHSD11B1 | |
| SCHEMBL29415408 | 0.66 | PTGS2 (0.61) | RAB9AALDH1A1KDM4EKMT2AHSD11B1 | |
| SCHEMBL8106699 | 0.66 | LOX (0.47) | RAB9AALDH1A1KDM4EHSD11B1LMNA | |
| SCHEMBL9212695 | 0.66 | BAZ2B (0.36) | BAZ2BBAZ2ARAB9AALDH1A1KDM4E | |
| SCHEMBL6820364 | 0.65 | CA2 (0.50) | BAZ2BBAZ2ARAB9AALDH1A1KDM4E | |
| SCHEMBL17922579 | 0.65 | HSD11B1 (0.47) | BAZ2BBAZ2ARAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679157-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994015932-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1994-07-21 | — | — | WO | disclosed |