Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652713 | 0.82 | DGAT1 (0.38) | SMN1; SMN2KMT2AALDH1A1GAAMEN1 | |
| SCHEMBL4563 | 0.81 | SMN1; SMN2 (0.42) | CA2SMN1; SMN2BRD4KMT2AKDM4E | |
| SCHEMBL445133 | 0.81 | SMN1; SMN2 (0.42) | CA2SMN1; SMN2BRD4KMT2AKDM4E | |
| SCHEMBL4562 | 0.81 | SMN1; SMN2 (0.42) | CA2SMN1; SMN2BRD4KMT2AKDM4E | |
| SCHEMBL16106147 | 0.81 | SMN1; SMN2 (0.42) | CA2SMN1; SMN2BRD4KMT2AKDM4E | |
| SCHEMBL2909384 | 0.79 | AR (0.41) | CA2SMN1; SMN2BRD4KMT2AALDH1A1 | |
| SCHEMBL30712604 | 0.78 | CA2 (0.38) | CA2SMN1; SMN2BRD4KMT2AKDM4E | |
| SCHEMBL2933208 | 0.78 | ALDH1A1 (0.36) | NOS1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL30712598 | 0.78 | CA2 (0.38) | CA2SMN1; SMN2BRD4KMT2AKDM4E | |
| SCHEMBL5037970 | 0.73 | L3MBTL1 (0.47) | SMN1; SMN2KMT2AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973546-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | Merck & Co., Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007081570-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |