Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | GLA | P06280 | 1/20 | 0.80 |
| ▸ | ST6GAL1 | P15907 | 10/20 | 0.70 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.65 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.61 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.61 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.61 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.59 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29356399 | 0.99 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| SCHEMBL5407898 | 0.99 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cystetine Triphosphate SCHEMBL9101211 | 0.97 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cystetine Triphosphate SCHEMBL10826769 | 0.96 | TSHR (0.80) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cystetine Triphosphate SCHEMBL31405617 | 0.96 | TSHR (0.80) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| SCHEMBL11616961 | 0.93 | TSHR (0.78) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cytarabine 5'-Phosphate SCHEMBL17978431 | 0.92 | TSHR (0.73) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cystetine Triphosphate SCHEMBL2194120 | 0.91 | TSHR (0.79) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Cystetine Triphosphate SCHEMBL11613107 | 0.91 | TSHR (0.79) | TSHRGLAST6GAL1P2RY2P2RY4 | |
| Choline SCHEMBL503814 | 0.91 | TSHR (0.81) | TSHRGLAST6GAL1P2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320807-A2 | Novel polynucleotide analogs, methods for inhibiting nucleic acid polymerases and methods for inducing synthesis of interferon | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1989-06-21 | — | — | EP | disclosed |