SCHEMBL5045263

SCHEMBL5045263

CCCCCCCCCCCCNC(=O)c1cc(Br)c(CNCc2cccc(OC(F)(F)F)c2)c(Br)c1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.48
NAMPT P43490 2/20 0.46
ROCK2 O75116 3/20 0.46
ROCK1 Q13464 2/20 0.46
MLYCD O95822 1/20 0.45
HDAC3 O15379 1/20 0.44
HDAC1 Q13547 1/20 0.44
AKR1C3 P42330 1/20 0.43
TRPV1 Q8NER1 1/20 0.43
DDR1 Q08345 1/20 0.42
EPHX2 P34913 2/20 0.41
HPGD P15428 2/20 0.41
LMNA P02545 1/20 0.41
NAAA Q02083 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C19 P33261 1/20 0.41
GLS O94925 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5044232 0.89 MAPK14 (0.49) MAPK14NAMPTROCK2ROCK1MLYCD
SCHEMBL6023308 0.88 MAPK14 (0.51) MAPK14NAMPTROCK2ROCK1HDAC1
SCHEMBL5045260 0.87 NAMPT (0.46) MAPK14NAMPTROCK2ROCK1MLYCD
SCHEMBL5043673 0.86 ALDH1A1 (0.50) MAPK14NAMPTMLYCDHDAC3HDAC1
SCHEMBL1851514 0.84 NAMPT (0.43) MAPK14NAMPTROCK2ROCK1MLYCD
SCHEMBL5039489 0.81 MLYCD (0.50) NAMPTMLYCDHDAC3HDAC1EPHX2
SCHEMBL6022152 0.80 DRD2 (0.43) MLYCDHPGDLMNANAAACYP1A2
SCHEMBL5044898 0.79 EPHX2 (0.51) HDAC3HDAC1AKR1C3TRPV1EPHX2
SCHEMBL5044219 0.79 MLYCD (0.48) MLYCDHDAC3HDAC1TRPV1EPHX2
SCHEMBL4323998 0.78 NAMPT (0.43) MAPK14NAMPTROCK2ROCK1MLYCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1732534-B1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS SERONO LAB (CH) 2008-07-23 EP claimed
EP-1732534-B1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS SERONO LAB (CH) 2008-07-23 EP disclosed
EP-1732534-A1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS Applied Research Systems ARS Holding N.V. (AN) 2006-12-20 EP disclosed
WO-2005082347-A1 USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2005-09-09 WO disclosed