Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | GCGR | P47871 | 2/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028396 | 0.89 | ADH5 (0.32) | — | |
| SCHEMBL13411813 | 0.86 | ADH5 (0.36) | — | |
| SCHEMBL17254440 | 0.80 | ESR1 (0.33) | — | |
| SCHEMBL184092 | 0.78 | DCUN1D1 (0.44) | METAP2 | |
| SCHEMBL1875818 | 0.78 | — | — | |
| SCHEMBL595369 | 0.78 | PKM (0.44) | — | |
| SCHEMBL1774400 | 0.78 | ALPL (0.46) | METAP2MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL705663 | 0.78 | NPC1 (0.40) | MAPK13GCGRMAPK12MAPK11MAPK14 | |
| SCHEMBL264036 | 0.78 | NPC1 (0.42) | METAP2 | |
| SCHEMBL595550 | 0.78 | IDO1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814366-B2 | Antiviral compounds and use thereof | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2023-11-14 | — | — | US | disclosed |
| EP-3765454-B1 | ANTIVIRAL COMPOUNDS AND USE THEREOF | UNIV DEGLI STUDI DI SIENA (IT) | 2023-11-08 | — | — | EP | disclosed |
| US-20210070737-A1 | ANTIVIRAL COMPOUNDS AND USE THEREOF | UNIVERSITA DEGLE STUDI DI SIENA (IT) | 2021-03-11 | — | — | US | disclosed |
| EP-3765454-A1 | ANTIVIRAL COMPOUNDS AND USE THEREOF | Universita' Degli Studi di Siena (IT) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019175436-A1 | ANTIVIRAL COMPOUNDS AND USE THEREOF | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2019-09-19 | — | — | WO | disclosed |
| US-9603852-B2 | Treatment of obesity and pulmonary arterial hypertension | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-9597310-B2 | Indanyloxydihydrobenzofuranylacetic acids | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-03-21 | — | — | US | disclosed |
| EP-2588197-B1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2014-11-05 | — | — | EP | disclosed |
| CN-100439357-C | Benzo [b][1,4] dioxepine derivatives | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |
| US-7459480-B2 | Benzodioxepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-7425555-B2 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1682528-B1 | BENZO [b][1,4] DIOXEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-09-12 | — | — | EP | disclosed |
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | disclosed |
| CN-1875015-A | Benzo [b][1,4] dioxepine derivatives | HOFFMANN LA ROCHE (CH) | 2006-12-06 | — | — | CN | disclosed |
| EP-1682528-A1 | BENZO [b][1,4] DIOXEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| US-20060089393-A1 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | GLAXOSMITHKLINE LLC | 2006-04-27 | — | — | US | disclosed |
| US-20050113374-A1 | Benzodioxepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-26 | — | — | US | disclosed |
| WO-2005044814-A1 | BENZO [b][1,4] DIOXEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-19 | — | — | WO | disclosed |
| EP-1499600-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003093248-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089393-A1 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | MAPK1, MAPK7, MAP3K1 | METAP2 2108/4885MAPK13 27/4885GCGR 3226/4885 |
| US-11814366-B2 | Antiviral compounds and use thereof | MAVS, EIF2AK2, SARS1 | METAP2 380/4885MAPK13 4345/4885GCGR 3929/4885 |
| US-20210070737-A1 | ANTIVIRAL COMPOUNDS AND USE THEREOF | MAVS, EIF2AK2, SARS1 | METAP2 380/4885MAPK13 4345/4885GCGR 3929/4885 |
| US-20050113374-A1 | Benzodioxepine derivatives | BBOX1, ACOX1, ACOX3 | METAP2 3306/4885MAPK13 3182/4885GCGR 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.