Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049449 | 0.90 | L3MBTL1 (0.43) | FABP4L3MBTL1NPC1POLBRAB9A | |
| SCHEMBL5133321 | 0.88 | FABP4 (0.49) | FABP4NPC1POLBRAB9AALDH1A1 | |
| SCHEMBL5043143 | 0.84 | KMT2A (0.51) | FABP4ALDH1A1KEAP1NFE2L2TRPM8 | |
| SCHEMBL81136 | 0.82 | FABP4 (0.58) | FABP4NPC1POLBRAB9ATRPM8 | |
| SCHEMBL5049388 | 0.81 | TAS2R14 (0.47) | NPC1POLBRAB9AALDH1A1KEAP1 | |
| SCHEMBL5046766 | 0.78 | FFAR1 (0.54) | POLBALDH1A1CA12CA1CA2 | |
| SCHEMBL14569572 | 0.77 | PTGDR2 (0.52) | L3MBTL1NPC1RAB9AALDH1A1TRPM8 | |
| SCHEMBL5048210 | 0.77 | ALDH1A1 (0.45) | POLBALDH1A1TRPM8MAPT | |
| SCHEMBL6059002 | 0.76 | ALDH1A1 (0.60) | L3MBTL1NPC1RAB9AALDH1A1CA12 | |
| SCHEMBL5050268 | 0.75 | NR3C1 (0.61) | CA12CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |