Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 4/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.63 |
| ▸ | RXRA | P19793 | 1/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | RXRB | P28702 | 1/20 | 0.63 |
| ▸ | RXRG | P48443 | 1/20 | 0.63 |
| ▸ | NR1H2 | P55055 | 10/20 | 0.62 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5061925 | 0.91 | KARS1 (0.71) | POLA1PDE4DKARS1RXRACCNE1 | |
| SCHEMBL2985191 | 0.89 | LMNA (0.64) | POLA1PDE4DKARS1RXRACCNE1 | |
| Podocaric Acid SCHEMBL32474685 | 0.86 | NR1H2 (0.80) | POLA1PDE4DKARS1RXRACCNE1 | |
| Podocaric Acid SCHEMBL6311820 | 0.86 | NR1H2 (0.80) | POLA1PDE4DKARS1RXRACCNE1 | |
| Podocaric Acid SCHEMBL31181390 | 0.86 | NR1H2 (0.80) | POLA1PDE4DKARS1RXRACCNE1 | |
| Podocaric Acid SCHEMBL14389445 | 0.86 | NR1H2 (0.80) | POLA1PDE4DKARS1RXRACCNE1 | |
| Podocaric Acid SCHEMBL160062 | 0.86 | NR1H2 (0.80) | POLA1PDE4DKARS1RXRACCNE1 | |
| SCHEMBL17934295 | 0.85 | POLA1 (0.71) | POLA1PDE4DKARS1RXRACCNE1 | |
| SCHEMBL20561119 | 0.85 | POLA1 (0.71) | POLA1PDE4DKARS1RXRACCNE1 | |
| Podocaric Acid SCHEMBL6312979 | 0.85 | NR1H2 (0.78) | POLA1PDE4DKARS1RXRACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125491-A1 | Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125491-A1 | Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders | GPR65, GPR3, GPR52 | POLA1 4692/4885PDE4D 521/4885KARS1 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.