Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680108 | 0.81 | PDE4B (0.42) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL27833081 | 0.73 | PDE4B (0.44) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL14674863 | 0.70 | MET (0.45) | BACE1MET | |
| SCHEMBL22025913 | 0.69 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DHSD17B10 | |
| SCHEMBL2203934 | 0.68 | FYN (0.50) | PDE4BPDE4APDE4CPDE4DFYN | |
| SCHEMBL2202989 | 0.68 | ACHE (0.40) | IKBKBHSD17B10ACHEBACE1TSHR | |
| SCHEMBL2849367 | 0.68 | ACHE (0.40) | IKBKBHSD17B10ACHEBACE1TSHR | |
| SCHEMBL9326316 | 0.68 | ALDH1A1 (0.54) | PDE4BPDE4APDE4CPDE4DIKBKB | |
| SCHEMBL12325398 | 0.67 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DIKBKB | |
| SCHEMBL1903608 | 0.67 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942904-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | Merck & Co., Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007041494-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | MERCK & CO., INC. (US) | 2007-04-12 | — | — | WO | disclosed |