SCHEMBL5077356

SCHEMBL5077356

CCOCC(CO[Si](C)(C)CCc1ccccc1)(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
HSD17B10 Q99714 2/20 0.37
SMN1; SMN2 Q16637 3/20 0.35
RAB9A P51151 2/20 0.35
NPC1 O15118 1/20 0.32
KDM4E B2RXH2 1/20 0.32
USP2 O75604 1/20 0.32
HPGD P15428 1/20 0.32
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31
SLC6A2 P23975 2/20 0.31
CHRM2 P08172 1/20 0.31
HTR1A P08908 1/20 0.31
ADRA2A P08913 1/20 0.31
CHRM1 P11229 1/20 0.31
DRD1 P21728 1/20 0.31
SLC6A4 P31645 1/20 0.31
ADRA1A P35348 1/20 0.31
OPRM1 P35372 1/20 0.31
DRD3 P35462 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5081735 0.91 TAAR1 (0.36) ALDH1A1HSD17B10SMN1; SMN2RAB9ANPC1
SCHEMBL5080806 0.90 ALDH1A1 (0.33) ALDH1A1HSD17B10SMN1; SMN2RAB9AKDM4E
SCHEMBL5075136 0.89 SMN1; SMN2 (0.33) ALDH1A1HSD17B10SMN1; SMN2RAB9ANPC1
SCHEMBL5080955 0.88 ALDH1A1 (0.32) ALDH1A1HSD17B10SMN1; SMN2RAB9ASLC6A2
SCHEMBL5081430 0.87 SLC6A2 (0.33) ALDH1A1HSD17B10TP53SLC6A2TAAR1
SCHEMBL5077300 0.86 ALDH1A1 (0.33) ALDH1A1HSD17B10SLC6A2TAAR1RECQL
SCHEMBL5075137 0.86 L3MBTL1 (0.34) ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E
SCHEMBL5078398 0.85 ALDH1A1 (0.33) ALDH1A1HSD17B10SMN1; SMN2RAB9ANPC1
SCHEMBL5075153 0.84 SLC6A2 (0.35) ALDH1A1HSD17B10SMN1; SMN2RAB9AHPGD
SCHEMBL5075249 0.83 RAB9A (0.36) ALDH1A1HSD17B10SMN1; SMN2RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7323431-B2 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-01-29 US claimed
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US claimed
US-7399812-B2 Silicon ether compounds and a method for the preparation thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-07-15 US disclosed
US-7323431-B2 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-01-29 US disclosed
US-20060183873-A1 Silicon ether compounds and a method for the preparation thereof BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2006-08-17 US disclosed
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US disclosed