SCHEMBL5081735

SCHEMBL5081735

C[Si](C)(CCc1ccccc1)OCC(CO[Si](C)(C)CCc1ccccc1)(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.36
SLC6A2 P23975 2/20 0.36
TDP1 Q9NUW8 2/20 0.35
LMNA P02545 2/20 0.34
CYP2D6 P10635 1/20 0.34
MAOA P21397 2/20 0.33
MAOB P27338 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MMP8 P22894 1/20 0.33
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
CHRM1 P11229 1/20 0.33
DRD1 P21728 1/20 0.33
SLC6A4 P31645 1/20 0.33
ADRA1A P35348 1/20 0.33
OPRM1 P35372 1/20 0.33
DRD3 P35462 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5075137 0.94 L3MBTL1 (0.34) TAAR1SLC6A2TDP1LMNACYP2D6
SCHEMBL5077356 0.91 ALDH1A1 (0.37) TAAR1SLC6A2NPC1RAB9ASMN1; SMN2
SCHEMBL5075136 0.89 SMN1; SMN2 (0.33) NPC1RAB9ASMN1; SMN2ALDH1A1HSD17B10
SCHEMBL5081803 0.87 SLC6A2 (0.36) TAAR1SLC6A2LMNACYP2D6NPC1
SCHEMBL5085428 0.84 SLC6A2 (0.34) TAAR1SLC6A2LMNACYP2D6SMN1; SMN2
SCHEMBL5085393 0.83 TDP1 (0.38) TAAR1SLC6A2TDP1LMNANPC1
SCHEMBL5081767 0.83 TAAR1 (0.38) TAAR1SLC6A2LMNACYP2D6SMN1; SMN2
SCHEMBL5085326 0.83 SLC6A2 (0.38) TAAR1SLC6A2LMNACYP2D6SMN1; SMN2
SCHEMBL8430157 0.83 POLB (0.39) TAAR1SLC6A2TDP1LMNANPC1
SCHEMBL5080899 0.83 NPC1 (0.35) TDP1LMNANPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7323431-B2 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-01-29 US claimed
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US claimed
US-7323431-B2 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-01-29 US disclosed
US-20060142146-A1 Catalyst for olefin polymerization and use of the same CHINA PETROLEUM & CHEMICAL CORPORATION 2006-06-29 US disclosed