Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5080898 | 1.00 | ALDH1A1 (0.44) | ALDH1A1LMNAGAATSHRHTT | |
| SCHEMBL13998295 | 0.81 | ALDH1A1 (0.45) | ALDH1A1LMNAGAATSHRSMN1; SMN2 | |
| SCHEMBL4854693 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNAGAATSHRSMN1; SMN2 | |
| SCHEMBL4854683 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNAGAATSHRSMN1; SMN2 | |
| SCHEMBL4862969 | 0.80 | MCOLN2 (0.47) | ALDH1A1LMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL4862980 | 0.80 | MCOLN2 (0.47) | ALDH1A1LMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL14010987 | 0.73 | HK1 (0.38) | ALDH1A1LMNAGAATSHRHTT | |
| SCHEMBL14011233 | 0.73 | SMN1; SMN2 (0.39) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4862055 | 0.73 | SMN1; SMN2 (0.39) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4863498 | 0.72 | ALDH1A1 (0.42) | ALDH1A1LMNATSHRSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014721-A1 | reacting oxabenzonorbornadiene with nucleophiles;in presence of rhodium complex catalyst forming 2-pyrrolidin-1-ol-1,2-dihydronaphthalen-1-ol; drug used as analgesics, Parkinson's disease, anticancer agents; aids | FAGNOU KEITH (CA) | 2005-01-20 | — | — | US | claimed |
| EP-1498406-A1 | Novel hydronaphthalene compounds, prepared by a rhodium catalysed ring opening reaction in the presence of phosphine ligand | AstraZeneca AB (SE) | 2005-01-19 | — | — | EP | claimed |
| EP-1228024-B1 | NOVEL HYDRONAPHTHALENE COMPOUNDS, PREPARED BY A RHODIUM CATALYZED RING OPENING REACTION IN THE PRESENCE OF PHOSPHINE LIGAND | ASTRAZENECA AB (SE) | 2004-09-01 | — | — | EP | claimed |
| US-20030144275-A1 | Decyclization of oxabenzonorbornadienes or azabicyclic compounds in the presence of catalysts to form naphthalenes, such as 2-methoxy-1,2-dihydronaphthalen-1-ol, used as analgesics, anticarcinogens or viricides; catalysis | ASTRAZENECA AB (SE) | 2003-07-31 | — | — | US | claimed |
| US-6525068-B1 | Such as 2-pyrrolidin-1-yl-1,2-dihydro-naphthalen-1-ol; reac-tion of oxabenzonorbornadienes with nucleophiles; pain, parkinson's disease, cancer, aids | ASTRAZENECA AB (SE) | 2003-02-25 | — | — | US | claimed |
| US-20080300271-A1 | Novel compounds and a novel process for their preparation | FAGNOU KEITH | 2008-12-04 | — | — | US | disclosed |
| EP-1498406-A1 | Novel hydronaphthalene compounds, prepared by a rhodium catalysed ring opening reaction in the presence of phosphine ligand | AstraZeneca AB (SE) | 2005-01-19 | — | — | EP | disclosed |
| EP-1228024-B1 | NOVEL HYDRONAPHTHALENE COMPOUNDS, PREPARED BY A RHODIUM CATALYZED RING OPENING REACTION IN THE PRESENCE OF PHOSPHINE LIGAND | ASTRAZENECA AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| US-6784210-B2 | DECYCLIZATION OF OXABENZONORBORNADIENES OR AZABICYCLIC COMPOUNDS IN THE PRESENCE OF CATALYSTS TO FORM NAPHTHALENES, SUCH AS 2-METHOXY-1,2-DIHYDRONAPHTHALEN-1-OL, USED AS ANALGESICS, ANTICARCINOGENS OR VIRICIDES; CATALYSIS | ASTRAZENECA AB (SE) | 2004-08-31 | — | — | US | disclosed |
| US-20030144275-A1 | Decyclization of oxabenzonorbornadienes or azabicyclic compounds in the presence of catalysts to form naphthalenes, such as 2-methoxy-1,2-dihydronaphthalen-1-ol, used as analgesics, anticarcinogens or viricides; catalysis | ASTRAZENECA AB (SE) | 2003-07-31 | — | — | US | disclosed |
| US-6525068-B1 | Such as 2-pyrrolidin-1-yl-1,2-dihydro-naphthalen-1-ol; reac-tion of oxabenzonorbornadienes with nucleophiles; pain, parkinson's disease, cancer, aids | ASTRAZENECA AB (SE) | 2003-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300271-A1 | Novel compounds and a novel process for their preparation | NUDT1, NCL, NUCB2 | ALDH1A1 3064/4885LMNA 2117/4885GAA 157/4885 |
| US-20050014721-A1 | reacting oxabenzonorbornadiene with nucleophiles;in presence of rhodium complex catalyst forming 2-pyrrolidin-1-ol-1,2-dihydronaphthalen-1-ol; drug used as analgesics, Parkinson's disease, anticancer agents; aids | PARK7, OPRD1, OPRK1 | ALDH1A1 523/4885LMNA 4871/4885GAA 618/4885 |
| US-20030144275-A1 | Decyclization of oxabenzonorbornadienes or azabicyclic compounds in the presence of catalysts to form naphthalenes, such as 2-methoxy-1,2-dihydronaphthalen-1-ol, used as analgesics, anticarcinogens or viricides; catalysis | DDT, HPD, DHODH | ALDH1A1 544/4885LMNA 4537/4885GAA 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.