SCHEMBL508267

SCHEMBL508267

C=C(C)C(=O)NCC(O)COCCC[Si](C)(C)C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CASR P41180 1/20 0.31
PLA2G2C Q5R387 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C19 P33261 1/20 0.31
KDM4E B2RXH2 1/20 0.30
USP2 O75604 1/20 0.30
ALDH1A1 P00352 1/20 0.30
ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9889663 0.85 CYP1A2 (0.40) PLA2G2CCYP1A2CYP3A4CYP2C19KDM4E
SCHEMBL508742 0.82 ZDHHC20 (0.31) CASRCYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL508173 0.82 CYP1A2 (0.31) CYP1A2CYP3A4CYP2C19KDM4EUSP2
SCHEMBL509068 0.82 CYP1A2 (0.31) CYP1A2CYP3A4CYP2C19KDM4EUSP2
SCHEMBL508829 0.79 USP2 (0.31) PLA2G2CCYP1A2CYP3A4CYP2C19KDM4E
SCHEMBL16038177 0.78 KDM4E (0.34) CYP1A2CYP3A4CYP2C19KDM4EUSP2
SCHEMBL528216 0.76 CYP1A2 (0.32) CYP1A2CYP3A4CYP2C19
SCHEMBL509069 0.76
SCHEMBL18204281 0.73 L3MBTL1 (0.33) CYP1A2CYP3A4CYP2C19
SCHEMBL1562994 0.73 HTT (0.53) CYP1A2CYP3A4CYP2C19USP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 368 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12638614-B2 Method for making silicone hydrogel contact lenses ALCON INC. (CH) 2026-05-26 US claimed
EP-4514596-B1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES ALCON INC (CH) 2026-03-04 EP claimed
US-20260042268-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES ALCON INC (CH) 2026-02-12 US claimed
US-20260042269-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES ALCON INC (CH) 2026-02-12 US claimed
EP-4657145-A2 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES Alcon Inc. (CH) 2025-12-03 EP claimed
EP-4657144-A2 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES Alcon Inc. (CH) 2025-12-03 EP claimed
US-20250223392-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC (CH) 2025-07-10 US claimed
US-12286501-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2025-04-29 US claimed
EP-4514596-A1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2025-03-05 EP claimed
EP-4514597-A1 METHOD FOR MAKING UV AND HEVL-ABSORBING OPHTHALMIC LENSES Alcon Inc. (CH) 2025-03-05 EP claimed
EP-1716436-B1 (METH) ACRYLAMIDE MONOMERS CONTAINING HYDROXY AND SILICONE FUNCTIONALITIES AND POLYMERS MADE THEREFROM JOHNSON & JOHNSON VISION CARE (US) 2011-04-06 EP claimed
WO-2010133680-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS NOVARTIS AG (CH) 2010-11-25 WO claimed
US-20100296049-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS ALCON INC. (CH) 2010-11-25 US claimed
US-20100258961-A1 Method for making silicone hydrogel contact lenses ALCON INC. (CH) 2010-10-14 US claimed
WO-2010071691-A1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES NOVARTIS AG (CH) 2010-06-24 WO claimed
US-20070167592-A1 (METH)ACRYLAMIDE MONOMERS CONTAINING HYDROXY AND SILICONE FUNCTIONALITIES JOHNSON & JOHNSON VISION CARE, INC. 2007-07-19 US claimed
US-7214809-B2 (Meth)acrylamide monomers containing hydroxy and silicone functionalities JOHNSON & JOHNSON VISION CARE, INC. (US) 2007-05-08 US claimed
EP-1716436-A1 (METH) ACRYLAMIDE MONOMERS CONTAINING HYDROXY AND SILICONE FUNCTIONALITIES AND POLYMERS MADE THEREFROM Johnson and Johnson Vision Care, Inc. (US) 2006-11-02 EP claimed
WO-2005078482-A1 (METH)ACRYLAMIDE MONOMERS CONTAINING HYDROXY AND SILICONE FUNCTIONALITIES AND POLYMERS MADE THEREFROM JOHNSON & JOHNSON VISION CARE, INC. (US) 2005-08-25 WO claimed
US-20050176911-A1 (Meth)acrylamide monomers containing hydroxy and silicone functionalities JOHNSON & JOHNSON VISION CARE, INC. 2005-08-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260042269-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES CRYZ, STRA6, PHOSPHO1 CASR 1300/4885PLA2G2C 45/4885CYP1A2 3826/4885
US-20100296049-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS VCL, MACF1, CFL1 CASR 2049/4885PLA2G2C 2594/4885CYP1A2 4509/4885
US-20260042268-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES STRA6, CRYZ, SMCHD1 CASR 1810/4885PLA2G2C 813/4885CYP1A2 2887/4885
US-12638614-B2 Method for making silicone hydrogel contact lenses SMCHD1, CRYAA, CRYZ CASR 3290/4885PLA2G2C 3106/4885CYP1A2 3211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.