Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 9/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19509672 | 0.85 | NPC1 (1.00) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL24158011 | 0.84 | NPC1 (0.59) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL444976 | 0.81 | MAPT (0.70) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL2012278 | 0.76 | ALDH1A1 (0.52) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL5082967 | 0.76 | NPC1 (0.52) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL6901556 | 0.75 | MAPT (0.56) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL6824227 | 0.75 | MAPT (0.70) | MAPTHSD17B10MEN1KMT2ATDP1 | |
| SCHEMBL5083060 | 0.75 | NPC1 (0.60) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL13363917 | 0.74 | MAPT (0.61) | NPC1RAB9AMAPTHSD17B10MAPK1 | |
| SCHEMBL1476308 | 0.73 | PTPRA (0.53) | NPC1RAB9AMAPTHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329542-B2 | HBV RNAse H purification and enzyme inhibitors | SAINT LOUIS UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-7375242-B2 | Catalysts for olefin polymerization | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| US-20030027957-A1 | Catalysts for olefin polymerization | HICKS FREDERICK (US) | 2003-02-06 | — | — | US | disclosed |
| US-6451940-B1 | THE USE OF AMINOTROPONES AS LIGANDS FOR NICKEL CONTAINING OLEFIN POLYMERIZATION CATALYSTS | E. I. DU PONT DE NEMOURS AND COMPANY | 2002-09-17 | — | — | US | disclosed |
| EP-1237951-A1 | CATALYSTS FOR OLEFIN POLYMERIZATIONS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001030865-A1 | CATALYSTS FOR OLEFIN POLYMERIZATIONS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2001-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329542-B2 | HBV RNAse H purification and enzyme inhibitors | RNASEH1, RNASE1, RNASEL | NPC1 660/4885RAB9A 2393/4885MAPT 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.