Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.65 |
| ▸ | MMP2 | P08253 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656156 | 0.89 | KDM4E (0.67) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL28082015 | 0.86 | MAOA (0.59) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL5087407 | 0.85 | LEF1 (0.55) | MMP13RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28081963 | 0.84 | NPC1 (0.60) | RAB9AKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5889575 | 0.84 | MMP13 (0.72) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL8205173 | 0.84 | MMP13 (0.72) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL931628 | 0.83 | NHERF1 (0.52) | RAB9ASMN1; SMN2NPC1LMNARXFP1 | |
| SCHEMBL14527880 | 0.83 | PYGL (0.48) | MMP13RAB9AKDM4EALDH1A1NPC1 | |
| SCHEMBL23258395 | 0.82 | MEN1 (0.57) | RAB9AKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL24601450 | 0.81 | MMP13 (0.72) | MMP13MMP2RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329760-B2 | CC-1065 analog synthesis | IMMUNOGEN INC. (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1492766-B1 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN INC (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1492766-A4 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1492766-A1 | IMPROVED CC-1065 ANALOG SYNTHESIS | Immunogen, Inc. (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003087055-A1 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN, INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| US-20030195365-A1 | CC-1065 analog synthesis | IMMUNOGEN INC. | 2003-10-16 | — | — | US | disclosed |
| US-6586618-B1 | Amination 1,3-dihydoxynaphthalene, then blocking, iodination, alkylation, cyclization and deblocking to give (5-hydroxy-3-amino-1-(S)-(chloromethyl)-1,2-dihydro-3H-benz(e)indole), used as chemical intermediates of antitumor agents | IMMUNOGEN INC. | 2003-07-01 | — | — | US | disclosed |
| US-6534660-B1 | Halogenation, alkylation and ring-closure of protected 2-amino-4-hydroxynaphthalene under suitable conditions to provide desired racemate, isolating (-) isomer, removing protecting groups | IMMUNOGEN, INC. | 2003-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195365-A1 | CC-1065 analog synthesis | DCUN1D5, DCUN1D1, DBN1 | MMP13 4316/4885MMP2 4388/4885RAB9A 3608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.