Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 2/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.45 |
| ▸ | RHEB | Q15382 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.44 |
| ▸ | CBR1 | P16152 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378425 | 0.85 | TDP1 (0.50) | EPAS1HSPB1MEN1KMT2AMAPT | |
| SCHEMBL16556058 | 0.83 | EPAS1 (0.63) | EPAS1HSPB1RHEBMEN1KMT2A | |
| SCHEMBL30856930 | 0.83 | EPAS1 (0.63) | EPAS1HSPB1RHEBMEN1KMT2A | |
| SCHEMBL10585649 | 0.82 | ALDH1A1 (0.53) | HPGDMEN1KMT2AMAPTTTR | |
| SCHEMBL21684753 | 0.81 | HSPB1 (0.64) | EPAS1HSPB1MEN1KMT2AMAPT | |
| Potassium Ion SCHEMBL10890394 | 0.80 | HPD (0.47) | EPAS1S1PR4RHEBHPGDMEN1 | |
| Monoethanolamine SCHEMBL10891249 | 0.79 | ALDH1A1 (0.50) | HPGDMEN1KMT2AMAPTTTR | |
| SCHEMBL1340557 | 0.78 | HSPB1 (0.56) | EPAS1S1PR4HSPB1HPGDMEN1 | |
| SCHEMBL11094809 | 0.78 | CHRM1 (0.69) | S1PR4SLC6A2SLC6A3MAPTTTR | |
| SCHEMBL640965 | 0.78 | HPGD (0.73) | S1PR4HSPB1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393873-B2 | Arylsulfonamide derivatives | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-20060142612-A1 | Arylsulfonamide derivatives | MERCK SHARP & DOHME CORP. | 2006-06-29 | — | — | US | disclosed |
| EP-1643960-A2 | ARYLSULFONAMIDE DERIVATIVES | Merck & Co., Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005004810-A2 | ARYLSULFONAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142612-A1 | Arylsulfonamide derivatives | BDKRB1, BDKRB2, LTB4R2 | EPAS1 137/4885S1PR4 696/4885HSPB1 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.