Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 3/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 11/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 10/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL53084 | 0.98 | HTT (0.55) | HTTCHKAACHEBCHEKDM4E | |
| SCHEMBL19946631 | 0.83 | MEN1 (0.54) | HTTCHKAACHEBCHEKDM4E | |
| Hydrochloric Acid SCHEMBL29538521 | 0.81 | MEN1 (0.52) | HTTCHKAACHEBCHEKDM4E | |
| Bromide SCHEMBL25241723 | 0.81 | MEN1 (0.41) | HTTCHKAKDM4EMEN1KMT2A | |
| Bromide SCHEMBL50687 | 0.80 | HTT (0.55) | HTTCHKAACHEBCHEKDM4E | |
| Bromide SCHEMBL30903821 | 0.80 | HTT (0.78) | HTTCHKAACHEBCHEMEN1 | |
| Bromide SCHEMBL26090899 | 0.80 | HTT (0.78) | HTTCHKAACHEBCHEMEN1 | |
| SCHEMBL12533280 | 0.79 | HTT (0.77) | HTTCHKAACHEBCHEKDM4E | |
| SCHEMBL18234751 | 0.79 | HTT (0.70) | HTTCHKAACHEBCHEKDM4E | |
| SCHEMBL25525834 | 0.79 | TP53 (0.41) | HTTCHKAACHEBCHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11253592-B2 | Water-soluble compounds with aggregation-induced emission characteristics | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2022-02-22 | — | — | US | disclosed |
| US-20200338196-A1 | WATER-SOLUBLE COMPOUNDS WITH AGGREGATION-INDUCED EMISSION CHARACTERISTICS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2020-10-29 | — | — | US | disclosed |
| WO-2016078603-A1 | AIE LUMINOGENS FOR BACTERIA IMAGING, KILLING, PHOTODYNAMIC THERAPY AND ANTIBIOTICS SCREENING, AND THEIR METHODS OF MANUFACTURING | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-05-26 | — | — | WO | disclosed |
| US-8357350-B2 | Annulus fibrosus detection in intervertebral discs using molecular imaging agents | GENERAL ELECTRIC COMPANY (US) | 2013-01-22 | — | — | US | disclosed |
| US-8129532-B2 | Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use | THE UNIVERSITY OF CONNECTICUT (US) | 2012-03-06 | — | — | US | disclosed |
| US-20100202965-A1 | ANNULUS FIBROSUS DETECTION IN INTERVERTEBRAL DISCS USING MOLECULAR IMAGING AGENTS | GENERAL ELECTRIC COMPANY (US) | 2010-08-12 | — | — | US | disclosed |
| US-20090042227-A1 | AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11253592-B2 | Water-soluble compounds with aggregation-induced emission characteristics | ROS1, POTEE, CD44 | CHKA 3656/4885ACHE 2909/4885HTT 2134/4885 |
| US-20200338196-A1 | WATER-SOLUBLE COMPOUNDS WITH AGGREGATION-INDUCED EMISSION CHARACTERISTICS | ROS1, POTEE, CD44 | CHKA 3656/4885ACHE 2909/4885HTT 2134/4885 |
| US-20090042227-A1 | AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE | NLN, NME4, OAT | CHKA 4164/4885ACHE 2187/4885HTT 1658/4885 |
| US-20100202965-A1 | ANNULUS FIBROSUS DETECTION IN INTERVERTEBRAL DISCS USING MOLECULAR IMAGING AGENTS | BMP1, TMEM14C, NPPA | CHKA 4508/4885ACHE 4124/4885HTT 2780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.