Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 10/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4724644 | 0.93 | CYP1A2 (0.46) | CYP1A2CYP19A1CYP2C9CYP2C19PDE5A | |
| SCHEMBL4724634 | 0.90 | ALDH1A1 (0.40) | HTR2BHTR2CPDE5AKDM4EALDH1A1 | |
| SCHEMBL10438816 | 0.73 | HTR7 (0.53) | CYP1A2CYP19A1CYP2C9CYP2C19HTR2B | |
| SCHEMBL4919270 | 0.71 | LTA4H (0.31) | — | |
| SCHEMBL4722144 | 0.68 | CYP1A2 (0.39) | CYP1A2CYP19A1CYP2C9CYP2C19HTR2B | |
| 1,2-Dipropoxybenzene SCHEMBL29428926 | 0.67 | CYP1A2 (0.56) | CYP1A2CYP2C9CYP2C19HTR2BHTR2C | |
| 1,2-Dipropoxybenzene SCHEMBL578657 | 0.67 | CYP1A2 (0.56) | CYP1A2CYP2C9CYP2C19HTR2BHTR2C | |
| SCHEMBL4722141 | 0.67 | CYP1A2 (0.40) | CYP1A2CYP19A1CYP2C9CYP2C19HTR2B | |
| SCHEMBL1389258 | 0.67 | ADRB2 (0.67) | ADRB2KDM4EALDH1A1LMNAKMT2A | |
| 1-Ethoxy-2-Propoxybenzene SCHEMBL2919156 | 0.66 | L3MBTL1 (0.64) | CYP1A2CYP2C9CYP2C19HTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | PFIZER INC. | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | TBXA2R, P2RY4, PF4 | CYP1A2 427/4885CYP19A1 1796/4885CYP2C9 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.