Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RHOC | P08134 | 2/20 | 0.37 |
| ▸ | RHOA | P61586 | 2/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935433 | 0.93 | TRPA1 (0.43) | TRPA1CYP1A2LMNAALDH1A1MRGPRX4 | |
| SCHEMBL5111277 | 0.91 | ALDH1A1 (0.46) | LMNAALDH1A1MRGPRX4TACR1MEN1 | |
| SCHEMBL4929708 | 0.90 | TRPA1 (0.47) | TRPA1CYP1A2LMNAALDH1A1TACR1 | |
| SCHEMBL4929668 | 0.89 | TRPA1 (0.48) | TRPA1CYP1A2LMNAALDH1A1TACR1 | |
| SCHEMBL5119858 | 0.89 | LMNA (0.44) | LMNAALDH1A1MRGPRX4TACR1RHOC | |
| SCHEMBL4931364 | 0.89 | LMNA (0.44) | LMNAALDH1A1MRGPRX4TACR1RHOC | |
| SCHEMBL4932487 | 0.87 | MEN1 (0.37) | LMNAMRGPRX4MEN1KMT2AMAPT | |
| SCHEMBL4935573 | 0.86 | PPARD (0.45) | TRPA1CYP1A2MRGPRX4SMN1; SMN2 | |
| SCHEMBL4933128 | 0.86 | TRPA1 (0.41) | TRPA1CYP1A2LMNAALDH1A1MRGPRX4 | |
| SCHEMBL4931997 | 0.86 | ALDH1A1 (0.46) | TRPA1LMNAALDH1A1MRGPRX4TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | KARO BIO AB (SE) | 2008-09-11 | — | — | US | disclosed |
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | TSHR, TRHR, THRA | TRPA1 675/4885CYP1A2 1307/4885LMNA 3893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.