Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | F11 | P03951 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813849 | 0.90 | PTGER1 (0.54) | HSD17B10L3MBTL1MAOBPTGER1PTGER4 | |
| SCHEMBL20954700 | 0.89 | MTNR1A (0.58) | MTNR1AMTNR1BHDAC8L3MBTL1TDP1 | |
| SCHEMBL21438534 | 0.89 | HSD17B10 (0.68) | MTNR1AMTNR1BHSD17B10HDAC8L3MBTL1 | |
| SCHEMBL1097150 | 0.89 | L3MBTL1 (0.61) | HSD17B10L3MBTL1TDP1MAOBPPARA | |
| SCHEMBL28451865 | 0.87 | HDAC8 (0.55) | MTNR1AMTNR1BHDAC8L3MBTL1TDP1 | |
| SCHEMBL9077083 | 0.86 | MTNR1B (0.60) | MTNR1AMTNR1BHSD17B10POLB | |
| SCHEMBL5779644 | 0.85 | MAOB (0.57) | MTNR1AMTNR1BHDAC8TDP1MAOB | |
| SCHEMBL5042727 | 0.85 | HDAC8 (0.53) | MTNR1AMTNR1BHDAC8TDP1MAOB | |
| SCHEMBL8965061 | 0.85 | ABCB1 (0.50) | MTNR1AMTNR1BHDAC8L3MBTL1TDP1 | |
| SCHEMBL17892024 | 0.84 | ABCB1 (0.66) | MTNR1AMTNR1BHSD17B10L3MBTL1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107868091-B | Meddigesin, derivatives thereof and preparation method thereof | 怀特生技新药股份有限公司 | 2020-08-28 | — | — | CN | disclosed |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | PHYTOHEALTH CORPORATION (TW) | 2019-08-20 | — | — | US | disclosed |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | PHYTOHEALTH CORPORATION (TW) | 2019-08-20 | — | — | US | disclosed |
| CN-107868091-A | Meddigesin, derivatives thereof and preparation method thereof | 怀特生技新药股份有限公司 | 2018-04-03 | — | — | CN | disclosed |
| US-20180086772-A1 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | PHYTOHEALTH CORPORATION (TW) | 2018-03-29 | — | — | US | disclosed |
| US-20180086772-A1 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | PHYTOHEALTH CORPORATION (TW) | 2018-03-29 | — | — | US | disclosed |
| EP-3299373-A2 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | PhytoHealth Corporation (TW) | 2018-03-28 | — | — | EP | disclosed |
| US-7329654-B2 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-12 | — | — | US | disclosed |
| US-7105679-B2 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | KANOJIA RAMESH M | 2006-09-12 | — | — | US | disclosed |
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-07-06 | — | — | US | disclosed |
| EP-1467998-B1 | TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS | ORTHO MCNEIL PHARM INC (US) | 2006-03-29 | — | — | EP | disclosed |
| EP-1569939-A1 | NOVEL HETEROATOM CONTAINING TETRACYCLIC DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2005-09-07 | — | — | EP | disclosed |
| CN-1620457-A | tetracyclic heterocyclic compounds as estrogen receptor modulators | ORTHO MCNEIL PHARM INC (US) | 2005-05-25 | — | — | CN | disclosed |
| US-20040259915-A1 | Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | KANOJIA RAMESH M (US) | 2004-12-23 | — | — | US | disclosed |
| EP-1467998-A1 | TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2004050660-A1 | NOVEL HETEROATOM CONTAINING TETRACYCLIC DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2004-06-17 | — | — | WO | disclosed |
| US-20030216463-A1 | Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-11-20 | — | — | US | disclosed |
| WO-2003053977-A1 | TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086772-A1 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | SHARPIN, TIPARP, MYADM | MTNR1A 640/4885MTNR1B 266/4885HSD17B10 2729/4885 |
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | GPR119, SLC5A1, CYP4B1 | MTNR1A 1225/4885MTNR1B 1038/4885HSD17B10 204/4885 |
| US-20040259915-A1 | Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | GPER1, ESR2, FSHR | MTNR1A 95/4885MTNR1B 149/4885HSD17B10 1359/4885 |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | SHARPIN, ATP6V1B1, REN | MTNR1A 1279/4885MTNR1B 431/4885HSD17B10 2165/4885 |
| US-20030216463-A1 | Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | GPER1, ESR2, FSHR | MTNR1A 95/4885MTNR1B 149/4885HSD17B10 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.