Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | MMP3 | P08254 | 3/20 | 0.35 |
| ▸ | MMP7 | P09237 | 3/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5141450 | 0.90 | MMP1 (0.40) | LMNASMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL5141453 | 0.89 | L3MBTL1 (0.42) | LMNASMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL5145690 | 0.86 | KMT2A (0.39) | LMNASMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL5142653 | 0.83 | MEN1 (0.43) | KMT2AMEN1 | |
| SCHEMBL5145792 | 0.83 | LMNA (0.41) | LMNASMN1; SMN2KMT2AALDH1A1PKM | |
| SCHEMBL5141474 | 0.81 | HSD11B1 (0.45) | KMT2AALDH1A1NAMPTMEN1 | |
| SCHEMBL4985250 | 0.78 | LMNA (0.40) | LMNASMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL4985245 | 0.78 | LMNA (0.38) | LMNASMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL5145783 | 0.78 | FAAH (0.40) | KMT2AALDH1A1HTTMEN1 | |
| SCHEMBL5142759 | 0.75 | MEN1 (0.43) | LMNASMN1; SMN2KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |