Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142465 | 0.86 | LMNA (0.40) | KMT2AMEN1MMP2MMP9LMNA | |
| SCHEMBL5141450 | 0.83 | MMP1 (0.40) | KMT2AMEN1MMP2LMNASMN1; SMN2 | |
| SCHEMBL5141453 | 0.82 | L3MBTL1 (0.42) | KMT2AMEN1MMP2MMP9LMNA | |
| SCHEMBL4989425 | 0.80 | MMP2 (0.40) | KMT2AMEN1LTA4HPTGS2MMP2 | |
| SCHEMBL4989418 | 0.80 | MEN1 (0.37) | KMT2AMEN1LTA4HPTGS2MMP2 | |
| SCHEMBL5142653 | 0.80 | MEN1 (0.43) | KMT2AMEN1 | |
| SCHEMBL5145792 | 0.80 | LMNA (0.41) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5141474 | 0.76 | HSD11B1 (0.45) | KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5145783 | 0.73 | FAAH (0.40) | KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL5142759 | 0.72 | MEN1 (0.43) | KMT2AMEN1LMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |