Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142775 | 0.89 | KDM2B (0.43) | MEN1KMT2ASCN9AAKR1C3KDM2B | |
| SCHEMBL5141453 | 0.86 | L3MBTL1 (0.42) | MEN1KMT2AHDAC6 | |
| SCHEMBL5141474 | 0.85 | HSD11B1 (0.45) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL5145792 | 0.85 | LMNA (0.41) | MEN1KMT2AKDM2B | |
| SCHEMBL5142465 | 0.83 | LMNA (0.40) | MEN1KMT2A | |
| SCHEMBL5144598 | 0.82 | KDM2B (0.42) | MEN1KMT2AAKR1C3KDM2BLIPE | |
| SCHEMBL5145690 | 0.80 | KMT2A (0.39) | MEN1KMT2A | |
| SCHEMBL5141450 | 0.79 | MMP1 (0.40) | MEN1KMT2A | |
| SCHEMBL4985230 | 0.78 | MEN1 (0.43) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL5142690 | 0.78 | HTT (0.48) | MEN1KMT2AGBA1KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |