Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5144601 | 0.84 | KMT2A (0.54) | KMT2AL3MBTL1MEN1 | |
| SCHEMBL5142653 | 0.82 | MEN1 (0.43) | KDM2BLIPEKMT2AAKR1C3MEN1 | |
| SCHEMBL5142775 | 0.79 | KDM2B (0.43) | KDM2BKMT2AL3MBTL1AKR1C3FGFR4 | |
| SCHEMBL4988098 | 0.79 | LIPE (0.42) | KDM2BCHRM1LIPEKMT2AL3MBTL1 | |
| SCHEMBL4988090 | 0.78 | CHRM1 (0.42) | KDM2BCHRM1LIPEKMT2AL3MBTL1 | |
| SCHEMBL5141474 | 0.76 | HSD11B1 (0.45) | KMT2AL3MBTL1MEN1 | |
| SCHEMBL5141465 | 0.75 | EPHX2 (0.40) | KMT2AL3MBTL1MEN1HTR6 | |
| SCHEMBL5141447 | 0.74 | L3MBTL1 (0.40) | KMT2AL3MBTL1MEN1 | |
| SCHEMBL5142573 | 0.74 | KMT2A (0.56) | KMT2AMEN1 | |
| SCHEMBL5142690 | 0.73 | HTT (0.48) | KDM2BKMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |