Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149061 | 0.92 | PLA2G7 (0.38) | ALDH1A1PTGS2 | |
| SCHEMBL2980527 | 0.86 | MRGPRX1 (0.33) | ALDH1A1MRGPRX1POLBPTGS1PTGS2 | |
| SCHEMBL5183961 | 0.86 | BRAF (0.34) | ALDH1A1 | |
| SCHEMBL5147495 | 0.85 | ALDH1A1 (0.36) | ALDH1A1MAPK1HTTLMNA | |
| SCHEMBL5146079 | 0.85 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1MAPK1HTTLMNA | |
| SCHEMBL5147455 | 0.81 | PLA2G7 (0.37) | ALDH1A1HTTLMNAPTGS2 | |
| SCHEMBL5179917 | 0.80 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1MAPK1HTTLMNA | |
| SCHEMBL5145984 | 0.78 | PLA2G7 (0.41) | ALDH1A1 | |
| SCHEMBL2988097 | 0.78 | PTGS2 (0.32) | ALDH1A1LMNAMEN1KMT2APTGS2 | |
| SCHEMBL5147462 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1MAPK1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |