Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986572 | 0.87 | MAOA (0.35) | MAOAMAOBLOX | |
| SCHEMBL5147484 | 0.85 | SMN1; SMN2 (0.37) | ALDH1A1LMNAMAPK1HTT | |
| SCHEMBL5149061 | 0.85 | PLA2G7 (0.38) | ALDH1A1 | |
| SCHEMBL5183961 | 0.84 | BRAF (0.34) | ALDH1A1 | |
| SCHEMBL5146079 | 0.81 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPK1HTT | |
| SCHEMBL5149221 | 0.80 | ALDH1A1 (0.39) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL5147380 | 0.79 | ALDH1A1 (0.40) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL2989836 | 0.76 | LOXL2 (0.30) | — | |
| SCHEMBL5179917 | 0.76 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPK1HTT | |
| SCHEMBL5147360 | 0.76 | CYP2A6 (0.35) | ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |