SCHEMBL51510

SCHEMBL51510

Cc1ccc(CC(C#N)(Cc2ccc(C)cc2)c2ccc(C)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 6/20 0.49
ESR2 Q92731 5/20 0.49
TSHR P16473 1/20 0.38
CYP2A6 P11509 2/20 0.37
ALDH1A1 P00352 2/20 0.37
IDO1 P14902 1/20 0.37
KIF11 P52732 2/20 0.36
PYCR1 P32322 1/20 0.35
CYP1A2 P05177 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
AGXT P21549 1/20 0.33
CASP1 P29466 1/20 0.33
HSD17B10 Q99714 1/20 0.33
BCHE P06276 1/20 0.33
ACHE P22303 1/20 0.33
LMNA P02545 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27708349 0.91 ESR1 (0.42) ESR1ESR2TSHRCYP2A6KIF11
SCHEMBL9447405 0.91 KIF11 (0.46) ESR1ESR2KIF11CYP1A2TAAR1
SCHEMBL28689681 0.80 ACHE (0.46) ALDH1A1CYP1A2TAAR1HSD17B10BCHE
SCHEMBL9447319 0.76 CASP1 (0.39) ESR1ESR2TSHRCYP2A6ALDH1A1
SCHEMBL2439798 0.75 ESR1 (0.43) ESR1ESR2TSHRCYP2A6ALDH1A1
SCHEMBL56267 0.75 ATM (0.53) ESR1ESR2ALDH1A1KIF11CYP1A2
SCHEMBL11841097 0.74 CASP1 (0.57) TSHRCYP2A6ALDH1A1KIF11CASP1
SCHEMBL9447544 0.74 ALDH1A1 (0.48) ESR1ESR2TSHRALDH1A1KIF11
SCHEMBL18801247 0.72 ESR1 (0.41) ESR1ESR2CYP2A6ALDH1A1IDO1
SCHEMBL11241939 0.71 ESR1 (0.36) ESR1ESR2CYP2A6ALDH1A1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8426596-B2 Process of producing bleach boosters BASF AKTIENGESELLSCHAFT (DE) 2013-04-23 US disclosed
US-8129531-B2 Using an isoquinoline compound; alkylation of benzonitrile; reduction ofnitrile to an amine; cyclization BASF AKTIENGESELLSCHAFT (DE) 2012-03-06 US disclosed
US-20110319622-A1 PROCESS OF PRODUCING BLEACH BOOSTERS BASF SE (DE) 2011-12-29 US disclosed
EP-1891192-B1 ORGANIC CATALYST WITH ENHANCED ENZYME COMPATIBILITY PROCTER & GAMBLE (US) 2009-12-16 EP disclosed
US-7504371-B2 Organic catalyst with enhanced enzyme compatibility THE PROCTER & GAMBLE COMPANY (US) 2009-03-17 US disclosed
US-20080214819-A1 Process of Producing Bleach Boosters BASF AKTIENGESELLSCHAFT (DE) 2008-09-04 US disclosed
EP-1896561-A2 PROCESS OF PRODUCING BLEACH BOOSTERS BASF SE (DE) 2008-03-12 EP disclosed
EP-1891192-A1 ORGANIC CATALYST WITH ENHANCED ENZYME COMPATIBILITY The Procter and Gamble Company (US) 2008-02-27 EP disclosed
US-20070197421-A1 Organic catalyst with enhanced enzyme compatibility PROCTER & GAMBLE COMPANY, THE 2007-08-23 US disclosed
WO-2007001261-A1 ORGANIC CATALYST WITH ENHANCED ENZYME COMPATIBILITY THE PROCTER & GAMBLE COMPANY (US) 2007-01-04 WO disclosed
WO-2006134144-A2 PROCESS OF PRODUCING BLEACH BOOSTERS BASF AKTIENGESELLSCHAFT (DE) 2006-12-21 WO disclosed
US-20060287210-A1 Organic catalyst with enhanced enzyme compatibility PROCTER & GAMBLE COMPANY, THE 2006-12-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214819-A1 Process of Producing Bleach Boosters SQLE, BCHE, CAT ESR1 2991/4885ESR2 2626/4885TSHR 3477/4885
US-20060287210-A1 Organic catalyst with enhanced enzyme compatibility AOX1, ACHE, MPO ESR1 1112/4885ESR2 2900/4885TSHR 4661/4885
US-20110319622-A1 PROCESS OF PRODUCING BLEACH BOOSTERS SQLE, BCHE, CAT ESR1 2991/4885ESR2 2626/4885TSHR 3477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.