Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tioconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.86 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.86 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.86 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.86 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.86 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.86 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.86 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.86 |
| ▸ | DRD2 | P14416 | 4/20 | 0.86 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.86 |
| ▸ | DRD3 | P35462 | 4/20 | 0.86 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.86 |
| ▸ | HTR2A | P28223 | 3/20 | 0.86 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.86 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.86 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.86 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.86 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tioconazole SCHEMBL5156492 | 1.00 | PGR (0.86) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL29408808 | 0.93 | PGR (1.00) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL41354 | 0.93 | PGR (1.00) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL41355 | 0.93 | PGR (1.00) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL29881791 | 0.93 | PGR (1.00) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL3682100 | 0.93 | PGR (1.00) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL29882046 | 0.93 | PGR (1.00) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL3682098 | 0.93 | PGR (1.00) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL7165886 | 0.92 | PGR (0.98) | PGRADORA3SLC6A2SLC6A4SLC6A3 | |
| Tioconazole SCHEMBL3722115 | 0.92 | PGR (0.98) | PGRADORA3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116063234-B | Preparation method of sulconazole nitrate | 山东京卫制药有限公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-116063234-A | Preparation method of sulconazole nitrate | 山东京卫制药有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-113318104-A | Application of sulconazole and/or sulconazole salt in preparing medicine for treating esophageal squamous cell carcinoma | 汕头大学医学院 | 2021-08-31 | — | — | CN | disclosed |
| CN-112955124-A | Oral film compositions and dosage forms having precise active dissolution profiles | 阿奎蒂夫疗法公司 | 2021-06-11 | — | — | CN | disclosed |
| CN-107847722-B | Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of use thereof | 辛纳吉勒公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-112534265-A | Screening method for preselecting individual for anti-cancer treatment and identifying individual susceptible to disease | TUDAG德累斯顿工业大学股份公司 | 2021-03-19 | — | — | CN | disclosed |
| CN-106572957-B | Skin color improving agent and composition for improving skin color | 昭和电工株式会社 | 2020-03-27 | — | — | CN | disclosed |
| CN-105744983-B | Device and method for sustained release of therapeutic agents of low water solubility in solubilizing agents | 纳米医学系统公司 | 2019-12-27 | — | — | CN | disclosed |
| EP-3185850-B1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | SHOWA DENKO KK (JP) | 2019-10-09 | — | — | EP | disclosed |
| US-20170312207-A1 | MOISTURIZING AGENT | SHOWA DENKO K.K. (JP) | 2017-11-02 | — | — | US | disclosed |
| EP-3213753-A1 | SKIN BARRIER FUNCTION-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN BARRIER FUNCTION | Showa Denko K.K. (JP) | 2017-09-06 | — | — | EP | disclosed |
| EP-3213739-A1 | AGENT FOR IMPROVING MITOCHONDRIAL FUNCTION AND ANTI-AGING COMPOSITION | Showa Denko K.K. (JP) | 2017-09-06 | — | — | EP | disclosed |
| EP-3185850-A1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | Showa Denko K.K. (JP) | 2017-07-05 | — | — | EP | disclosed |
| US-20170143608-A1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | SHOWA DENKO K.K. (JP) | 2017-05-25 | — | — | US | disclosed |
| WO-2016031634-A1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | SHOWA DENKO K. K. (JP) | 2016-03-03 | — | — | WO | disclosed |
| EP-1740668-B1 | ADHESIVE FOR DERMAL PATCH AND PRODUCTION PROCESS THEREOF | SHOWA DENKO KK (JP) | 2015-06-10 | — | — | EP | disclosed |
| US-20070219286-A1 | Adhesive For Dermal Patch And Production Process Thereof | SHOWA DENKO K.K. (JP) | 2007-09-20 | — | — | US | disclosed |
| EP-1740668-A1 | ADHESIVE FOR DERMAL PATCH AND PRODUCTION PROCESS THEREOF | SHOWA DENKO KABUSHIKI KAISHA (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2006112533-A1 | WATER-CONTAINING GEL FORM AND PRODUCTION METHOD THEREOF | SHOWA DENKO K.K. (JP) | 2006-10-26 | — | — | WO | disclosed |
| WO-2005103184-A1 | ADHESIVE FOR DERMAL PATCH AND PRODUCTION PROCESS THEREOF | SHOWA DENKO K. K. (JP) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219286-A1 | Adhesive For Dermal Patch And Production Process Thereof | ASIC1, SLC9A1, COL1A1 | PGR 3232/4885ADORA3 643/4885SLC6A2 541/4885 |
| US-20170143608-A1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | RBP4, RBP1, RARA | PGR 935/4885ADORA3 1778/4885SLC6A2 3121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.