Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157820 | 0.87 | DRD2 (0.38) | PDE10ASIRT2SIRT1NNMTMTNR1A | |
| SCHEMBL2274817 | 0.84 | TAAR1 (0.38) | SIRT2SIRT1NNMTTXNRD1TAAR1 | |
| SCHEMBL5157847 | 0.84 | LATS1 (0.36) | PDE10ATXNRD1DRD2DRD3 | |
| SCHEMBL2541350 | 0.82 | KDM4E (0.37) | NNMTMTNR1AMTNR1BTDP1 | |
| SCHEMBL2268818 | 0.82 | NNMT (0.37) | PDE10ASIRT2SIRT1NNMTPOLB | |
| SCHEMBL2536177 | 0.81 | NNMT (0.36) | SIRT2SIRT1NNMTMTNR1AMTNR1B | |
| SCHEMBL5155277 | 0.81 | HRH3 (0.43) | SIRT2SIRT1NNMTMTNR1AMTNR1B | |
| SCHEMBL995460 | 0.78 | NOS1 (0.34) | — | |
| SCHEMBL5157392 | 0.78 | CRHR1 (0.40) | DRD2DRD3 | |
| SCHEMBL5157405 | 0.77 | OPRM1 (0.32) | NNMTMTNR1AMTNR1BHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551360-B1 | 6-ALKOXY-2,3-DIAMINOPYRIDINE COUPLERS IN WHICH THE POSITION 2 AMINO RADICAL IS A DISUBSTITUTED AMINO RADICAL AND USE OF SAID COUPLERS FOR THE DYEING OF KERATINOUS FIBRES | OREAL (FR) | 2007-01-24 | — | — | EP | claimed |
| US-20060090270-A9 | Novel 6-alkoxy-2, 3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | VIDAL LAURENT | 2006-05-04 | — | — | US | claimed |
| EP-1551360-A1 | NOVEL 6-ALKOXY-2,3-DIAMINOPYRIDINE COUPLERS IN WHICH THE POSITION 2 AMINO RADICAL IS A DISUBSTITUTED AMINO RADICAL AND USE OF SAID COUPLERS FOR THE DYEING OF KERATINOUS FIBRES | L'OREAL (FR) | 2005-07-13 | — | — | EP | claimed |
| WO-2004030643-A1 | NOVEL 6-ALKOXY-2,3-DIAMINOPYRIDINE COUPLERS IN WHICH THE POSITION 2 AMINO RADICAL IS A DISUBSTITUTED AMINO RADICAL AND USE OF SAID COUPLERS FOR THE DYEING OF KERATINOUS FIBRES | L'OREAL (FR) | 2004-04-15 | — | — | WO | claimed |
| US-7238211-B2 | 6-alkoxy-2,3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | L'OREAL S.A. (FR) | 2007-07-03 | — | — | US | disclosed |
| US-7238211-B2 | 6-alkoxy-2,3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | L'OREAL S.A. (FR) | 2007-07-03 | — | — | US | disclosed |
| US-7238211-B2 | 6-alkoxy-2,3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | L'OREAL S.A. (FR) | 2007-07-03 | — | — | US | disclosed |
| EP-1551360-B1 | 6-ALKOXY-2,3-DIAMINOPYRIDINE COUPLERS IN WHICH THE POSITION 2 AMINO RADICAL IS A DISUBSTITUTED AMINO RADICAL AND USE OF SAID COUPLERS FOR THE DYEING OF KERATINOUS FIBRES | OREAL (FR) | 2007-01-24 | — | — | EP | disclosed |
| EP-1551360-B1 | 6-ALKOXY-2,3-DIAMINOPYRIDINE COUPLERS IN WHICH THE POSITION 2 AMINO RADICAL IS A DISUBSTITUTED AMINO RADICAL AND USE OF SAID COUPLERS FOR THE DYEING OF KERATINOUS FIBRES | OREAL (FR) | 2007-01-24 | — | — | EP | disclosed |
| US-20060090270-A9 | Novel 6-alkoxy-2, 3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | VIDAL LAURENT | 2006-05-04 | — | — | US | disclosed |
| US-20050086747-A1 | Novel 6-alkoxy-2, 3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060090270-A9 | Novel 6-alkoxy-2, 3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | KRT18, QDPR, PYCR1 | PDE10A 4654/4885SIRT2 2496/4885SIRT1 4209/4885 |
| US-20050086747-A1 | Novel 6-alkoxy-2, 3-diaminopyridine couplers in which the amino radical in position 2 is a disubstituted amino radical, and use of these couplers for dyeing keratin fibres | KRT18, QDPR, PYCR1 | PDE10A 4654/4885SIRT2 2496/4885SIRT1 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.