Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15331284 | 0.89 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL17244330 | 0.84 | KDM4E (0.48) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL5161888 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL28402701 | 0.82 | MTNR1A (0.55) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL5159539 | 0.81 | KIF11 (0.43) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL5158018 | 0.80 | MAOA (0.43) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL15332438 | 0.80 | PTGS2 (0.58) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL28873648 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1120931 | 0.79 | KDM4E (0.62) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL14154118 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010044-A1 | 3-INDOLYLMETHYLENE DERIVATIVES WITH CYTOSTATIC ACTION | UNIVERSITAET REGENSBURG (DE) | 2007-01-25 | — | — | WO | disclosed |
| EP-1746087-A1 | Derivates of 3-indolylmethylene having cytostatic properties | Universitaet Regensburg (DE) | 2007-01-24 | — | — | EP | disclosed |