Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027698 | 0.82 | PRSS1 (0.44) | MAPTPRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL5160556 | 0.78 | NAAA (0.43) | CYP3A4GPR84FFAR1MAPTLCK | |
| SCHEMBL5158154 | 0.76 | GPR84 (0.34) | GPR84FFAR1FOLH1MAPTLCK | |
| SCHEMBL7097299 | 0.76 | KMT2A (0.44) | CYP3A4MAPTCNR2 | |
| SCHEMBL5158364 | 0.76 | HCAR2 (0.36) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL5162386 | 0.75 | GPR84 (0.33) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL3033757 | 0.74 | GPR84 (0.52) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL5160445 | 0.74 | LMNA (0.48) | MAPT | |
| SCHEMBL5162981 | 0.74 | GPR84 (0.34) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL5177516 | 0.74 | TRPA1 (0.47) | TRPA1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340746-B1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | SALTIGO GMBH (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1340746-A1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | BAYER AG (DE) | 2003-09-03 | — | — | EP | disclosed |