Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166736 | 0.73 | NFE2L2 (0.51) | NFE2L2KCNH2HTR6PTGES2 | |
| SCHEMBL5164020 | 0.73 | TSHR (0.41) | HTR6CYP3A4CYP2C9CYP2C19SYK | |
| SCHEMBL4425113 | 0.72 | SYK (0.56) | PTPRCPTPN1SYK | |
| SCHEMBL28541778 | 0.71 | HTR6 (0.77) | HTR6 | |
| SCHEMBL5165214 | 0.70 | MEN1 (0.48) | — | |
| SCHEMBL21471580 | 0.70 | PTPRC (0.47) | PTPRCPTPN1SYK | |
| SCHEMBL7932563 | 0.69 | ERN1 (0.44) | NFE2L2SYK | |
| SCHEMBL5248910 | 0.68 | HTR6 (0.55) | NFE2L2KCNH2HTR6 | |
| SCHEMBL8552729 | 0.68 | CA2 (0.53) | PTGES2PTGS1PTGS2CYP2C9 | |
| SCHEMBL9693255 | 0.67 | NAMPT (0.45) | PTGS2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |