Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165214 | 0.81 | MEN1 (0.48) | TSHRCASP1CASP7SMN1; SMN2HSD17B10 | |
| SCHEMBL11135262 | 0.76 | POLB (0.45) | TSHRHTR7KDM4EHPGDMAPK1 | |
| SCHEMBL29038341 | 0.73 | ALOX5AP (0.46) | HTR7ALDH1A1MAPTPOLBCYP2C9 | |
| SCHEMBL5164016 | 0.73 | NFE2L2 (0.48) | HTR6SYKCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5166737 | 0.72 | L3MBTL1 (0.45) | SMN1; SMN2HTR6KDM4EHPGDTP53 | |
| SCHEMBL4425113 | 0.72 | SYK (0.56) | SMN1; SMN2HTR7SYKKDM4EMAPK1 | |
| SCHEMBL28835130 | 0.71 | ALDH1A1 (0.50) | SMN1; SMN2HTR6KDM4EALDH1A1POLB | |
| SCHEMBL4247206 | 0.70 | HTR6 (0.58) | SMN1; SMN2HTR6KDM4ETP53POLB | |
| SCHEMBL13370774 | 0.70 | HTR6 (0.58) | SMN1; SMN2HTR6KDM4ETP53GLA | |
| SCHEMBL5165342 | 0.70 | ALDH1A1 (0.52) | SMN1; SMN2HSD17B10HTR7HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |