Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 8/20 | 0.33 |
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163491 | 0.86 | CA2 (0.39) | TDP1CYP3A4TSHRFDPS | |
| SCHEMBL11531630 | 0.83 | GPR84 (0.44) | FDPS | |
| SCHEMBL14123404 | 0.81 | CHRM1 (0.37) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL25824 | 0.81 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL26940428 | 0.81 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL5165606 | 0.80 | — | — | |
| SCHEMBL17227619 | 0.79 | CHRM1 (0.36) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL4692524 | 0.79 | CA1 (0.39) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL28091198 | 0.79 | ALDH1A1 (0.40) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL17227618 | 0.79 | CHRM1 (0.36) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1772150-A1 | Benzothiophene formulations of a specific dosage | Eli Lilly & Company (US) | 2007-04-11 | — | — | EP | disclosed |
| US-20060106010-A1 | Methods for inhibiting bone loss | ELI LILLY AND COMPANY | 2006-05-18 | — | — | US | disclosed |
| US-RE39049-E1 | Methods for inhibiting bone loss | ELI LILLY AND COMPANY (US) | 2006-03-28 | — | — | US | disclosed |
| US-RE38968-E1 | Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride | ELI LILLY AND COMPANY (US) | 2006-02-07 | — | — | US | disclosed |
| US-6906086-B2 | Methods for inhibiting bone loss | ELI LILLY AND COMPANY (US) | 2005-06-14 | — | — | US | disclosed |
| EP-1438957-A1 | Benzothiophene formulations of a specific dosage | ELI LILLY AND COMPANY (US) | 2004-07-21 | — | — | EP | disclosed |
| US-20030212058-A1 | Methods for inhibiting bone loss | ELI LILLY AND COMPANY | 2003-11-13 | — | — | US | disclosed |
| EP-1238667-A2 | Use of benzothiophenes for treatment of hypercholesterolaemia | ELI LILLY AND COMPANY (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-0693285-B1 | Pharmaceutical compositions containing a bisphosphonate and an anti-resorptive agent for inhibiting bone loss | LILLY CO ELI (US) | 2002-02-06 | — | — | EP | disclosed |
| US-20010051636-A1 | Combination treatment for inhibiting bone loss | BLACK LARRY J (US) | 2001-12-13 | — | — | US | disclosed |
| US-5457117-A | Method for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[B][2-(piperidin-1-yl)ethoxyphenylimethanone hydrochloride | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5441964-A | Especially post-memopausal women | ELI LILLY AND COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0665015-A2 | Combination treatment for osteoporosis | ELI LILLY AND COMPANY (US) | 1995-08-02 | — | — | EP | disclosed |
| EP-0657162-A1 | Methods for lowering serum cholesterol | ELI LILLY AND COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |
| EP-0651998-A1 | Methods for inhibiting bone loss | ELI LILLY AND COMPANY (US) | 1995-05-10 | — | — | EP | disclosed |
| EP-0650724-A1 | Methods for inhibiting uterine fibrosis | ELI LILLY AND COMPANY (US) | 1995-05-03 | — | — | EP | disclosed |
| US-5393763-A | Administering benzothiophenes such as raloxifene hydrochloride | ELI LILLY AND COMPANY (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0635264-A2 | Antiestrogens as hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1995-01-25 | — | — | EP | disclosed |
| EP-0605193-A1 | Use of benzothiophenes for treatment of hypercholesterolaemia | ELI LILLY AND COMPANY (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0584952-A1 | Improvements in or relating to benzothiophenes | ELI LILLY AND COMPANY (US) | 1994-03-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106010-A1 | Methods for inhibiting bone loss | SHBG, SOST, ESRRB | CHRM1 3543/4885AKR1A1 1113/4885CHRM3 1633/4885 |
| US-20030212058-A1 | Methods for inhibiting bone loss | SHBG, SOST, ESRRB | CHRM1 3543/4885AKR1A1 1113/4885CHRM3 1633/4885 |
| US-20010051636-A1 | Combination treatment for inhibiting bone loss | SOST, BMP2, PTH1R | CHRM1 4573/4885AKR1A1 982/4885CHRM3 3872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.