Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6183891 | 0.99 | MEN1 (0.54) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6183804 | 0.99 | MEN1 (0.54) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6183815 | 0.92 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6640195 | 0.92 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL12881570 | 0.84 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2658539 | 0.84 | MAPT (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3552981 | 0.83 | MEN1 (0.55) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5026735 | 0.82 | MAPT (0.51) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL11490414 | 0.81 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL372350 | 0.81 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
| US-20060194811-A1 | Pyrimidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-08-31 | — | — | US | disclosed |
| US-20060161004-A1 | Novel compounds | GLAXOSMITHKLINE SPA | 2006-07-20 | — | — | US | disclosed |
| EP-1595869-A1 | PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-11-16 | — | — | EP | disclosed |
| US-20050070574-A1 | Novel compounds | GLAXOSMITHKLINE SPA AND LABORATOIRE | 2005-03-31 | — | — | US | disclosed |
| US-20040102633-A1 | Novel compounds | GLAXOSMITHKLINE S.P.A. (IT) | 2004-05-27 | — | — | US | disclosed |
| EP-1339691-A1 | NOVEL COMPOUNDS | GlaxoSmithKline S.p.A. (IT) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002044154-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE SPA (IT) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070574-A1 | Novel compounds | NR1H3, NR1H2, CNR1 | MEN1 3329/4885KMT2A 3392/4885ALDH1A1 2641/4885 |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | LTA4H, LTB4R, LTC4S | MEN1 4858/4885KMT2A 3196/4885ALDH1A1 1142/4885 |
| US-20060161004-A1 | Novel compounds | SLC10A1, ABCB11, AQP1 | MEN1 318/4885KMT2A 4394/4885ALDH1A1 1265/4885 |
| US-20060194811-A1 | Pyrimidine derivatives | ADORA3, NR4A1, NR0B1 | MEN1 2884/4885KMT2A 2616/4885ALDH1A1 1991/4885 |
| US-20040102633-A1 | Novel compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1, NR1H3 | MEN1 3121/4885KMT2A 4037/4885ALDH1A1 2127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.