SCHEMBL5181635 — predicted protein targets

Known targets — ChEMBL curated mechanism

ABCC8 ACE ADORA1 ADORA2A ADORA2B ADORA3 ALDH5A1 ALOX5 ALOX5AP ATP4A ATP4B BRAF CA1 CA12 CA2 CA4 CYSLTR1 DHFR DPEP1 EDNRA EDNRB ESR2 F10 FDPS FGF1 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GART GNRHR GSC1 HMGCR IMPDH1 IMPDH2 KCNJ11 LY96 NOD2 NR3C1 NS3 NS4A NS5b P2RY1 P2RY12 P2RY2 P2RY4 P2RY6 PBP2X PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDK1 PDK2 PDK3 PDK4 PPARG PPAT PTGIR PTGS1 PTGS2 RAF1 RYR1 RYR3 SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SERPINC1 SLC12A1 SLC12A3 SYK THRA THRB TLR3 TLR4 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TYMS VKORC1 XDH bla blaIMP-1 blaOXA-33 blaOXA-58 blaT-3 blaT-4 blaT-5 blaT-6 dacA dacB dacC folA folP folP1 ftsI fusA gag gyrA gyrB mecA mrcA mrcB mrdA pbp1a pbp1b pbp2 pbp2a pbp2b pbp3 pbp4 pbpA pbpB pbpC pbpF pol ponB rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpoA rpoB rpoC rpoZ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	THRB known ✓	P10828	1/20	0.48

▸	SLC28A3	Q9HAS3	4/20	0.54

▸	AKR1B1	P15121	1/20	0.49

▸	KDM4E	B2RXH2	4/20	0.48

▸	HPGD	P15428	4/20	0.48

▸	CASP1	P29466	4/20	0.48

▸	CASP7	P55210	4/20	0.48

▸	HSD17B10	Q99714	4/20	0.48

▸	ALDH1A1	P00352	3/20	0.48

▸	GLA	P06280	3/20	0.48

▸	GAA	P10253	2/20	0.48

▸	MEN1	O00255	2/20	0.48

▸	KMT2A	Q03164	2/20	0.48

▸	CYP2C19	P33261	1/20	0.48

▸	AMY1A	P0DUB6	1/20	0.48

▸	STAT6	P42226	1/20	0.48

▸	TYR	P14679	1/20	0.48

▸	USP2	O75604	2/20	0.48

▸	NPC1	O15118	1/20	0.48

▸	TNNI3	P19429	1/20	0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5348342	0.96	SLC28A3 (0.54)	SLC28A3KDM4EHPGDCASP1CASP7
SCHEMBL4367986	0.96	SLC28A3 (0.54)	SLC28A3KDM4EHPGDCASP1CASP7
SCHEMBL5181812	0.87	USP2 (0.60)	SLC28A3AKR1B1KDM4EHPGDCASP1
SCHEMBL3232003	0.87	USP2 (0.60)	SLC28A3AKR1B1KDM4EHPGDCASP1
SCHEMBL13576873	0.87	USP2 (0.60)	SLC28A3AKR1B1KDM4EHPGDCASP1
SCHEMBL13577086	0.87	USP2 (0.60)	SLC28A3AKR1B1KDM4EHPGDCASP1
SCHEMBL5181117	0.84	SLC28A3 (0.56)	SLC28A3AKR1B1TDP1
SCHEMBL5181436	0.83	USP2 (0.57)	SLC28A3KDM4EHPGDCASP1CASP7
SCHEMBL4375057	0.83	USP2 (0.57)	SLC28A3KDM4EHPGDCASP1CASP7
SCHEMBL722959	0.83	USP2 (0.57)	SLC28A3KDM4EHPGDCASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20220362124-A1	HAIR BLEACHING COMPOSITIONS AND METHODS OF USE	ELC MAN LLC (US)	2022-11-17	—	—	US	claimed
US-11298308-B1	Hair bleaching compositions and methods of use	ELC MANAGEMENT LLC (US)	2022-04-12	—	—	US	claimed
EP-4337162-A1	HAIR BLEACHING COMPOSITIONS AND METHODS OF USE	ELC Management LLC (US)	2024-03-20	—	—	EP	disclosed
US-11602497-B2	Hair bleaching compositions and methods of use	ELC MANAGEMENT LLC (US)	2023-03-14	—	—	US	disclosed
WO-2022241166-A1	HAIR BLEACHING COMPOSITIONS AND METHODS OF USE	ELC MANAGEMENT LLC (US)	2022-11-17	—	—	WO	disclosed
US-20220362124-A1	HAIR BLEACHING COMPOSITIONS AND METHODS OF USE	ELC MAN LLC (US)	2022-11-17	—	—	US	disclosed
US-11298308-B1	Hair bleaching compositions and methods of use	ELC MANAGEMENT LLC (US)	2022-04-12	—	—	US	disclosed
US-7282520-B2	External preparation	LION CORPORATION (JP)	2007-10-16	—	—	US	disclosed
EP-1437119-B1	EXTERNAL PREPARATION CONTAIINING GALLIC ACID DERIVATIVES	LION CORP (JP)	2007-08-15	—	—	EP	disclosed
US-20040247551-A1	External preparation	LION CORPORATION (JP)	2004-12-09	—	—	US	disclosed
EP-1437119-A1	EXTERNAL PREPARATION	Lion Corporation (JP)	2004-07-14	—	—	EP	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20220362124-A1	HAIR BLEACHING COMPOSITIONS AND METHODS OF USE	CAT, TYR, GPX1	THRB 1124/4885SLC28A3 1446/4885AKR1B1 1928/4885
US-20040247551-A1	External preparation	GANAB, GANC, EEA1	THRB 3541/4885SLC28A3 1003/4885AKR1B1 2043/4885
US-11602497-B2	Hair bleaching compositions and methods of use	CAT, TYR, GPX1	THRB 1124/4885SLC28A3 1446/4885AKR1B1 1928/4885
US-11298308-B1	Hair bleaching compositions and methods of use	CAT, TYR, GPX1	THRB 1124/4885SLC28A3 1446/4885AKR1B1 1928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.