Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186125 | 0.88 | HSD17B10 (0.40) | HSD17B10PKMTP53MAPK1ALDH1A1 | |
| SCHEMBL5221159 | 0.72 | LMNA (0.39) | HSD17B10PKMTP53MAPK1ALDH1A1 | |
| SCHEMBL5429111 | 0.72 | LMNA (0.36) | HSD17B10PKMTP53MAPK1ALDH1A1 | |
| SCHEMBL5223383 | 0.71 | CTSD (0.47) | HSD17B10PKMTP53MAPK1ALDH1A1 | |
| SCHEMBL5219617 | 0.71 | HSD17B10 (0.50) | HSD17B10ALDH1A1CASP6TDP1L3MBTL1 | |
| SCHEMBL5429108 | 0.70 | LRRK2 (0.43) | HSD17B10PKMTP53MAPK1ALDH1A1 | |
| SCHEMBL2738014 | 0.70 | OPRK1 (0.49) | HSD17B10TP53ALDH1A1TDP1MAPT | |
| SCHEMBL3187893 | 0.69 | LMNA (0.39) | HSD17B10PKMTP53MAPK1ALDH1A1 | |
| SCHEMBL16935198 | 0.68 | HSD17B10 (0.40) | HSD17B10ALDH1A1MAPTSMN1; SMN2CYP2C9 | |
| SCHEMBL5216498 | 0.68 | BACE1 (0.47) | HSD17B10MAPK1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |