Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PTAFR | P25105 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197239 | 0.88 | GSK3B (0.43) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5184337 | 0.81 | MAOA (0.42) | ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL3544822 | 0.76 | TOP2A (0.42) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5224541 | 0.74 | GBA1 (0.44) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2000744 | 0.70 | GBA1 (0.42) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL17844229 | 0.70 | MEN1 (0.48) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5307781 | 0.66 | LTA4H (0.69) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2733241 | 0.63 | CHRNA7 (0.52) | — | |
| SCHEMBL12286471 | 0.62 | ACHE (0.52) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2943040 | 0.62 | PIK3CD (0.70) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838687-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006073366-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | claimed |
| WO-2016100619-A2 | TREATMENT AND DIAGNOSIS OF CANCER | RGENIX, INC. (US) | 2016-06-23 | — | — | WO | disclosed |