Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | PTAFR | P25105 | 5/20 | 0.44 |
| ▸ | KDM6B | O15054 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844133 | 0.89 | KDM6B (0.43) | GBA1KDM6BKDM4CASAH1KAT2B | |
| SCHEMBL5184329 | 0.89 | TYMP (0.42) | KDM6BKDM4CASAH1KAT2BASPH | |
| SCHEMBL17844195 | 0.83 | ASPH (0.41) | KDM6BKDM4CASAH1ALDH1A1KAT2B | |
| SCHEMBL5185609 | 0.74 | ALDH1A1 (0.43) | GBA1PTAFRKDM6BKDM4CNPC1 | |
| SCHEMBL17844110 | 0.73 | MAOA (0.40) | KDM6BKDM4CASAH1ASPHKDM8 | |
| SCHEMBL17844245 | 0.72 | CYP1A2 (0.42) | NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL17844216 | 0.71 | EPHX1 (0.40) | ASAH1ASPHKDM8GSK3B | |
| SCHEMBL1998360 | 0.71 | PTAFR (0.47) | GBA1PTAFRKDM6BKDM4CASAH1 | |
| SCHEMBL9706440 | 0.67 | LTA4H (0.63) | GBA1PTAFRKDM6BKDM4CALDH1A1 | |
| SCHEMBL6159259 | 0.67 | SIGMAR1 (0.67) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100619-A2 | TREATMENT AND DIAGNOSIS OF CANCER | RGENIX, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| EP-1838687-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073366-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |