Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663018 | 0.96 | LTA4H (0.60) | LTA4HTSHRLMNASLC6A3HRH3 | |
| SCHEMBL7301909 | 0.94 | LMNA (0.59) | LTA4HTSHRLMNASLC6A3HRH3 | |
| SCHEMBL5788869 | 0.83 | SIGMAR1 (0.59) | LTA4HTSHRSLC6A3SIGMAR1 | |
| SCHEMBL4438692 | 0.83 | POLB (0.53) | LTA4HTSHRLMNASIGMAR1HTT | |
| SCHEMBL13992754 | 0.82 | TSHR (0.47) | LTA4HTSHRLMNASIGMAR1TEAD3 | |
| SCHEMBL5188945 | 0.79 | TEAD3 (0.52) | TSHRLMNATEAD3 | |
| SCHEMBL29447351 | 0.77 | LTA4H (0.87) | LTA4HSLC6A3HRH3SIGMAR1HTT | |
| SCHEMBL6393260 | 0.76 | LTA4H (0.84) | LTA4HLMNASLC6A3HRH3SIGMAR1 | |
| Cyclohexane SCHEMBL8149682 | 0.75 | TSHR (0.83) | LTA4HTSHRLMNA | |
| SCHEMBL22440218 | 0.74 | LTA4H (0.77) | LTA4HSLC6A3HRH3SIGMAR1TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118530239-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-115626927-B | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-115697989-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115626927-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-01-20 | — | — | CN | disclosed |