Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193168 | 0.90 | RAB9A (0.47) | GAALMNATP53KMT2ANPC1 | |
| SCHEMBL5192873 | 0.83 | LMNA (0.47) | GAALMNAKMT2APDE5A | |
| SCHEMBL5191071 | 0.83 | LMNA (0.47) | GAALMNAKMT2APDE5A | |
| SCHEMBL5278574 | 0.79 | LMNA (0.48) | GAALMNANPC1PDE5A | |
| SCHEMBL5193999 | 0.78 | ALDH1A1 (0.46) | GAALMNANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5190702 | 0.77 | GAA (0.49) | GAALMNAKMT2ATSHRWDR5 | |
| SCHEMBL5190763 | 0.77 | RXFP1 (0.46) | GAALMNAKMT2APDE5AL3MBTL1 | |
| SCHEMBL5195631 | 0.77 | TSHR (0.48) | GAAKMT2AHTTTSHRALDH1A1 | |
| SCHEMBL5190136 | 0.76 | EPHX2 (0.52) | GAAKMT2AHTTTSHRALDH1A1 | |
| SCHEMBL5190900 | 0.76 | POLB (0.49) | GAAKMT2ANPC1NPSR1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |