Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195331 | 0.87 | GAA (0.49) | POLBGAAKMT2AMAPTALDH1A1 | |
| SCHEMBL5193335 | 0.82 | SMN1; SMN2 (0.49) | POLBNAMPTGAAKMT2ATDP1 | |
| SCHEMBL5191071 | 0.79 | LMNA (0.47) | PDE5AGAAKMT2AMAPT | |
| SCHEMBL5192873 | 0.79 | LMNA (0.47) | PDE5AGAAKMT2AMAPT | |
| SCHEMBL5193168 | 0.78 | RAB9A (0.47) | POLBGAAKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5191525 | 0.76 | NOS2 (0.57) | — | |
| SCHEMBL5278574 | 0.76 | LMNA (0.48) | PDE5AGAANPC1 | |
| SCHEMBL5207369 | 0.76 | GAA (0.42) | POLBPDE5AGAAKMT2AL3MBTL1 | |
| SCHEMBL5193999 | 0.75 | ALDH1A1 (0.46) | POLBGAAMAPTALDH1A1NPC1 | |
| SCHEMBL5190702 | 0.74 | GAA (0.49) | GAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |