Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190296 | 0.86 | SIGMAR1 (0.44) | ALDH1A1KDM4ESIRT2SIRT1OPRM1 | |
| SCHEMBL5190544 | 0.84 | ALDH1A1 (0.56) | KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL5190692 | 0.81 | ALDH1A1 (0.48) | KMT2AALDH1A1KDM4EOPRM1 | |
| SCHEMBL5193050 | 0.78 | KMT2A (0.41) | KMT2AALDH1A1MEN1 | |
| SCHEMBL5191954 | 0.75 | KMT2A (0.44) | KMT2AALDH1A1MEN1POLBSIRT2 | |
| SCHEMBL5192506 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPT | |
| SCHEMBL31317528 | 0.73 | SIGMAR1 (0.52) | KMT2AALDH1A1KDM4EMEN1POLB | |
| SCHEMBL5190175 | 0.72 | ALDH1A1 (0.45) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL25154352 | 0.72 | SLC6A2 (0.47) | KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL5193849 | 0.72 | HRH3 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |