Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190544 | 0.91 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1LMNAKMT2AMAPK1 | |
| SCHEMBL5190296 | 0.85 | SIGMAR1 (0.44) | ALDH1A1L3MBTL1OPRM1OPRK1KDM4E | |
| SCHEMBL5193050 | 0.81 | KMT2A (0.41) | ALDH1A1L3MBTL1LMNAKMT2A | |
| SCHEMBL5192506 | 0.81 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1LMNAMAPK1KDM4E | |
| SCHEMBL5192022 | 0.81 | KMT2A (0.48) | ALDH1A1KMT2AOPRM1KDM4E | |
| SCHEMBL5191068 | 0.80 | LMNA (0.44) | ALDH1A1L3MBTL1LMNAKMT2ACCR3 | |
| SCHEMBL5192869 | 0.80 | OPRK1 (0.46) | L3MBTL1LMNAKMT2ACCR3MAPK1 | |
| SCHEMBL5190175 | 0.79 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1LMNAKMT2AKDM4E | |
| SCHEMBL5193163 | 0.79 | SMN1; SMN2 (0.44) | ALDH1A1L3MBTL1LMNAKMT2ACCR3 | |
| SCHEMBL5193992 | 0.78 | SMN1; SMN2 (0.48) | ALDH1A1LMNAKMT2AUTS2ROPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |