Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5192869 | 0.87 | OPRK1 (0.46) | LMNACCR3L3MBTL1MAPK1EGFR | |
| SCHEMBL5191068 | 0.86 | LMNA (0.44) | LMNACCR3L3MBTL1MAPK1POLB | |
| SCHEMBL5193908 | 0.86 | LMNA (0.42) | LMNAMAPK1 | |
| SCHEMBL5190760 | 0.84 | ALDH1A1 (0.49) | MAPK1POLBGFERALDH1A1 | |
| SCHEMBL5193992 | 0.81 | SMN1; SMN2 (0.48) | LMNAGFERKDM4EALDH1A1 | |
| SCHEMBL5194076 | 0.79 | ALDH1A1 (0.44) | LMNAKDM4EALDH1A1 | |
| SCHEMBL5193163 | 0.79 | SMN1; SMN2 (0.44) | LMNACCR3L3MBTL1MAPK1POLB | |
| SCHEMBL5190656 | 0.76 | KMT2A (0.53) | L3MBTL1MAPK1POLBNPC1GFER | |
| SCHEMBL5207365 | 0.76 | LMNA (0.41) | LMNACCR3L3MBTL1MAPK1POLB | |
| SCHEMBL5190692 | 0.75 | ALDH1A1 (0.48) | LMNACCR3L3MBTL1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |